کارِ سعادت
قیاس ذاتی کسی بھی اعتراض گزار کی بنیادی قوت ہوتی ہے جسے وہ شعور (خود ساختہ شعور جو آرٹ کے درجے میں ہے) کے ذریعے کسی معروضی حقیقتِ مطلق کو اپنے شعور کے مطابق قیاس کر کے مسرور ہوتا ہے تبھی کہا جاتا ہے خود سے یگانگی حقیقت سے بیگانگی کے مترادف ہوتی ہے۔ ہرہیچ مدان و ناتواں کو اپنے عقلِ کل ہونے کا زعم وقوف سے عاری کرتا ہے اس لیے مضحکہ خیز اعتراضات کو فتوحات گردانتا ہے۔ حالاں کہ راست علم ہمیشہ کسی واقعی معروض کی تمیز سے اٹھتا ہے یعنی موجود پر قوتِ امتیاز یا وجدانی ادراک کے ذریعے جوہر کے اسما و شناخت کا سفر طے کیا جاتا ہے۔ ہر چند ہر مذہب موضوعِ علم بننے کی پوری استطاعت رکھتا ہے۔ ہاں مگر ناظر کاصاحبِ وجدان ہونا ازحد ضروری ہوتا ہے۔ چوں کہ ہر قضیہ وجدانی ادراک کے متحرک ہونے سے جنم لیتا ہے۔ ہم زمان و مکان کا ادراک اسی استعداد کی تحریک سے کرتے ہیں۔ اسی لیے ایک طے شدہ امر ہے کہ شعور ِ علمی کی تشکیل میں خارجی معروض کا ہونا بنیادی حیثیت کا حامل ہے۔ اگر خارجی معروض اور اس سے منسوب شعورِ انسانی میں مطابقت نہ ہو تو قضیہ کے بجائے بے بنیاد مناقشات ظہور کرتے ہیں ،جن پہ خارجی واقعیت دلالت نہیں کرتی اور نتیجہ خیز حقانیت کی راہیں بھی برابر مسدود ہوتی جاتی ہیں۔ جب معترضین اپنے خود ساختہ علم کا قابلِ قبول شعور پیدا کرنے سے قاصر ہو جاتے ہیں تو اس کی غلط توجیہات پر قانع ہونے کے شعور سے بھی ہاتھ دھو بیٹھتے ہیں۔ اکثر یوں ہوتا ہے کہ نظریاتی تسکین جب بھی ضرورت سے زیادہ بڑھ جاتی ہے تو معیاری اور یقینی علم کو محال کر دیتی ہے۔
اعتراض محاذ تب بنتا ہے جب علمی کے بجائے ذاتی تسکین...
This paper explores the religious ideological basis, cultural ambivalence and a bicultural identity issues in Mohsin Hamid’s The Reluctant Fundamentalist. This Pakistani Anglophone novel carries different diasporic sensibilities. Issues related to culture, religion and its association with ideological grounds are very prominent. Elements of immigrant feelings and loss of identity are very vibrant. The writer shares migrant experience and the influence of a new culture of the host country, United States. While migrants from some of the Asian states, mainly those characterized by most recent immigrant waves, have really worse socio-economic situation than average immigrants; Pakistani people are among minorities. This research is qualitative in nature. Theories presented by Arjun Appadurai, Homi K Bhabha, and James Clifford about culture and diaspora support this research. This research is helpful to know about the concerns associated with the liminal space and issues related to identity loss, strong affiliation and recognition on the basis of religion and living with a bicultural identity.
Coronopus didymus is a medicinal plant used traditionally as antipyretic, expectorant, blood purifier and for alleviating symptoms of pain, inflammations, malaria, wounds and cancer. The present study was designed with the objectives of revelation of diagnostic compounds responsible for biological activity of this plant. This work is divided into two main parts, part I includes extraction, preliminary phytochemical analysis, isolation, purification, and identification of phenolic constituents by using mass spectrometric technique. Part II comprises bioevaluation of plant for cytotoxic, antioxidant and antimicrobial activities. Total phenolic content of various solvent extracts was determined using the Folin-Ciocalteu assay. Polar and non-polar constituents of C. didymus were identified by ultra performance liquid chromatography-electrospray ionization-mass spectrometric (UPLC-ESI-MS) and gas-chromatography-mass spectrometric analysis (GC-MS), respectively. Major constituents of C. didymus were isolated by using Sephadex LH-20 column chromatography and preparative mass directed HPLC method. The phenolic content was found to be the highest in the ethanolic extract (CDA Et, 47.8 mM GAE). Eighteen phytochemicals were tentatively identified from ethanolic extract by UPLC-ESI-MS analysis. The predominant compounds of aerial parts were flavonoids while roots contained glucosinolate as the major component. Sixty-three volatile phytochemicals were identified from aerial parts and roots of C. didymus by GC-MS analyses. Mass spectrometric profiling of the C. didymus extracts, confirmed that this plant contained a plenty of compounds. The structures of isolated compounds were elucidated by UV-Vis. spectroscopy (with shift reagents), LC-ESI-MS and NMR spectral data as 5,7,4''trihydroxy-3''-methoxyflavone-4''-O-β-D-glucoside (1''), 5,7,4''-trihydroxy-3''methoxyflavone-4''-O-(6''''-acetyl)b -D-glucoside (2'') and 5,7,4''-trihydroxy-3''-methoxy flavone (3''). Compound 1'' was identified for the first time from the genus Coronopus. Extracts, fractions and isolated compounds were subjected to various bioassays in a dose dependent manner to understand their anticancer, antioxidant, antifungal and antibacterial susceptibility. Isolated compounds 1''-3'' showed promising activity against HeLa cells with IC50 values of 43.50, 0.63 and 3.67 µM, respectively. Significant result was also obtained with compound 3'' against LN18 cells with IC50 value of 46.63 µM. In antioxidant activity, compound 3'' was far more effective in scavenging free radicals in the DPPH and ABTS assays with IC50 of 43.8 and 0.08 µg/mL, than the standard trolox, with IC50 values of 97.5 and 21.1 µg/mL, respectively. Compound 3'' depicted largest zone of inhibition (15 mm) against X. campestris, which was even higher than the chemical bactericides viz., bismerthiazole and kasugamycin, with inhibition zone of 11 mm and 14 mm, respectively. Mass spectrometric profiling and the cytotoxic, antioxidant and antimicrobial activity of the phenolic constituents 1''-3'' provide a scientific basis for the ethnopharmacological use of C. didymus for various applications.