عقیدہ تناسخ اور عہد الست میں فرق کے حوالے سے امام رازی کے موقف کا جائزہ

Reincarnation is a basic Hindu belief according to which the soul of a person is recreated for second time in different shapes according to their different actions. It is known as the belief of Samsara or reincarnation in Hinduism. If the person who passes away is good, his soul is transferred into a beautiful and nice body like that of birds etc. But if he is an evil person, his soul is transferred into ugly insects and animals etc. According to this belief, the difference between two human beings is due to the difference in their previous action or “karma” that he has committed in his previous birth. Human actions cannot be fruitful in this world and this is why a second birth is needed. This belief is wrong from Shariah perspective and it contradicts the basic Islamic belief of resurrection. Reincarnation assumes that there is no specific day on which actions will be rewarded; rather it is Auagun or Juni Cycle through which a human being deserves positive or negative reward. Imam Razi has refuted this belief through both logical and textual evidences. He has also replied the objections raised against the covenant of “alast”. (الست) According to Shariah, there is a second world beyond this physical for reward or punishment of deeds which is known as the Day of Judgment Doomsday.  On this day, the Scale will be set and human actions will be weighed. Consequently, he will deserve either Paradise or hell. Paradise is an abode of perpetual rest and satisfaction whereas hell is a place of humiliation and degradation.  

Kras Oncogenic Mutation Pattern in Pakistani Patients Presenting With Colorectal Adenocarcinoma in a Northern Tertiary Referal Centre

Veterinary Pathology Pathology Abstract Colorectal cancer is a global disease with marked morbidity and mortality. Involvement of genetic and environmental factors produces variability in its prevalence. KRAS (Kirsten rat sarcoma viral oncogene homologue) is one of the important genes responsible for sporadic CRC. The constitutive GTPase activity of the gene is lost when it gets mutated and so the deregulated cells undergo unrestricted proliferation leading to oncogenesis. From therapeutic point of view, patients with KRAS mutations do not benefit from epidermal growth factor receptor inhibition drugs as those who possess normal KRAS. The analysis of KRAS mutations is therefore important from both diagnostic as well as therapeutic purposes. Diagnostic methodology and the valuable information of this study will be quite helpful in future. The objectives of this study were to document the KRAS oncogenic mutation pattern mostly in Northern Pakistani residents presenting in AFIP, Rawalpindi after their intestinal resection due to CRC. The other objective was to relate this mutation pattern with histopathological categorical variables like age, gender, presenting clinical complaint, tumor site, size, histological differentiation, modified Duke Stage of tumor, nodal metastasis and metastasis in other organs. Hundred and eighty one cases of CRC from persons residing in northern area of Pakistan were collected and observed for the above mentioned parameters. DNA was extracted from the tumors and normal tissues of all the study subjects. PCR was done for gene amplification and the status of KRAS mutations in Pakistani CRC patients was analyzed by gene sequencing. The results showed more prevalence of CRC in the males of northern areas of Pakistan. Both males and females with higher average age had high tendency to acquire CRC. Rectum was found to be the most common location of CRC, followed by sigmoid. Exophytic well differentiated adenocarcinomas were the most common form of CRC. Gene sequencing did not show even a single KRAS mutation in the tested samples. It can be inferred from this study that either there is no KRAS mutation in northern area patients suffering from CRC or the mutation frequency of this particular gene is relatively very low as compared to the results of studies reported in the literature. A wider scale study of these patients may prove the cause of CRC to be due to mutation of some other genes or may be due to some non-genetic factors.