مولانا یعقوب مجددی بھوپالی
افسوس ہے کہ گذشتہ مہینے حضرت مولانا محمد یعقوب صاحب مجدوی بھوپالی نے انتقال فرمایا، موصوف کو حضرت مجدد الف ثانی ؒ سے نسبی اور خاندانی تعلق بھی تھا، وہ اس دور کے عارف کامل اور نامور شیخ تھے، ان کی خانقاہ ارشاد و ہدایت کا مرکز تھی اور اس سے بڑا فیض پہنچا، راقم کو بھی ان کی خدمت میں حاضری اور کئی مجلسوں میں شرکت کی سعادت حاصل ہوئی معلوم ہوتا تھا علم و عرفان کا چشمہ ابل رہا ہے اور دلوں کی کھیتیاں سیراب ہورہی ہیں، میری حاضری کے وقت حضرت کی عمر اسّی (۸۰) سال کے قریب رہی ہوگی، خلقتہً بھی نحیف تھے، لیکن روحانی قوت کا یہ حال تھا کہ گھنٹوں پورے جوش کے ساتھ تقریر و ملفوظات کا سلسلہ جاری رہتا تھا اور یہ روزانہ کامعمول تھا، آپ کے ملفوظات و مواعظ علم و عرفان کا گنجینہ ہیں، جہاں تک معلوم ہے ان کو قلم بند کرنے کا اہتمام نہیں کیا گیا، مولانا علی میاں نے کچھ مجلسوں کے ملفوظات قلم بند کئے تھے، جو الفرقان میں شائع ہوچکے ہیں، اگر تمام ملفوظات و مواعظ قلم بند ہوکر شائع ہوگئے ہوتے تو علم و عرفان کا یہ گنجینہ ہمیشہ کے لیے محفوظ ہو جاتا، ان کی وفات سے ارشاد و ہدایت کی ایک نورانی شمع گل ہوگئی، اﷲ تعالیٰ ان کے مدارج بلند فرمائے۔ (شاہ معین الدین ندوی، جون ۱۹۷۰ء)
Liver plays an important role in lipid metabolism and any acute or chronic malfunction of the liver due to viral hepatitis or liver cirrhosis may induce lipid derangements Objective: To determine the patterns of deranged lipid profiles in patients of chronic hepatitis C Methods: It is a prospective, observational study, conducted at Medicine Department, Mayo Hospital Lahore for 6 months i.e.1stJanuary to 30th June 2018. After the ethical approval, 160 diagnosed cases of chronic hepatitis C of ages 18-70 years of either gender were selected by non-probability purposive sampling. Informed written consent was taken. Demographic information such as name, age and gender were recorded. Venous blood samples from patients after 10 to 14 hours of fasting were drawn for lipid profiles and sent to pathology laboratory. All results were expressed as mg/dl. Data were analyzed in SPSS version 22 Results: Out of 160 patients in this study, there were 94 males and 66 females. Total cholesterol was lower in 62.5% patients, normal in 33.75% patients and higher in 3.75% patients. Triglycerides levels were low in 66.25%, normal in 33.125%, and high in 0.625% patients. Low density lipoprotein (LDL) levels were low in 82.5% patients, normal in 10% and raised in 7.5% patients. High density lipoprotein (HDL) levels were low in 95%, normal in 4.375% & high in 0.625% patients Conclusions: Low levels of serum lipids including total cholesterol, triglycerides, LDL and HDL are seen in population suffering from chronic HCV infection.
Organochloride pesticides (OCPs) also known as ―endocrine disrupting‖ chemicals are one of the persistent group of contaminants in soil that has gained worldwide concerns over the past few decades. They can transferred into the vegetables grown on the contaminated soils and eventually entered the food chain. The associated risk to human health makes the remediation of pesticide-contaminated soil a crucial undertaking. This research work is divided into different parts and several experiments were conducted to achieve the proposed objectives. The first study was carried out to evaluate the concentrations of OCPs in soils and vegetables grown in selected sites of Khyber Pakhtunkhwa (KP), Pakistan. The soil and selected vegetable species including Spinacia oleracea, Raphanus sativus, Brassica rapa, Lactuca sativa, Allium cepa and Allium sativum were collected from six districts (Peshawar, Charsadda, Nowshera, Mardan, Swabi and Swat), and were analysed for selected OCPs. Results showed that the concentrations of the selected OCPs exceeded their respective maximum residue limits (MRLs) in most of the soil samples and showed great variation from site to site. In case of the studied vegetables, the most contaminated observed was Lactuca sativa (28.9 μg kg-1), followed by Raphanus sativus (26.6 μg kg-1), Spinacia oleracea (25.8 μg kg-1), Allium cepa (16.3 μg kg-1), Brassica rapa (15.6 μg kg-1), and Allium sativum (14.7 μg kg-1). Analysis of health risk revealed that incremental lifetime cancer risks (ILCR) associated with dietary exposure of Σ30OCP through vegetables consumption by adults and children were below the acceptable risk level (10-6), indicating no cancer risk to the consumers. Moreover, exposure to the endocrine disruptor and probable carcinogen heptachlor epoxide (in children only) contributes toward non-cancer risk (HQ>1) from ingestion of selected vegetables. The presence of the banned OCPs in soils and vegetables in xvi the study area indicates that these legacy chemicals are still being used illegally for agricultural purposes which may be a cause for concern. Similarly, the second study was focused on the remediation of OCP-contaminated soils, as most of the OCPs are known to be possible/suspected endocrine disruptors and carcinogenic in nature and may severely affect humans or other living biota. Therefore, a 65-d incubation experiment was conducted to investigate the efficacy of biochars on the accessibility of OCPs, and also to evaluate their influence on soil microbial community. Results indicated that despite greater persistence of OCPs in soil, the application of selected biochars significantly (p<0.01) reduced the accessibility of åOCPs in contaminated soil as compared to the control soil during 65-days incubation period. Moreover, the findings from total phospholipid acid (PLFA) and Illumina next-generation sequencing revealed that the incorporation of biochar have altered the soil microbial community structure over time. Higher abundances of Proteobacteria, Firmicutes, Gemmatimonadetes, and Actinobacteria, were found in the biochar amendments. This recommends that biochar amendment (3%) could be advantageous for sustaining soil microbial communities and may thus likely influence the eco-toxicological processes and potential accumulation of OCPs. The third study was conducted to evaluate the effects of biochar (BC), biochar-based organic fertilizer (OF) and their combination (BCOF) on the bioaccessibility and accumulation of endocrine disruptive pesticides (EDPs) into leafy vegetables (Lactuca sativa and Spinacia oleracea) grown in a contaminated soil. The results revealed that application of BCOF and OF significantly (p<0.05) decreased bioaccessible concentrations of åEDPs in leafy vegetables by 23 and 44%, respectively, BC was particularly effective and decreased åEDPs bio-accessible concentrations by 60%, as compared to control. Biomass production, however, xvii increased the most for the BCOF amendments, (with a 70% increase in crop production compared to the control soil). Moreover, the incremental lifetime cancer risk (ILCR) values for selected EDPs were significantly (p<0.01) reduced in the amended soil as compared to control. These findings suggest that OF, BCOF and BC could be useful soil amendments to minimize the EDPs bioaccessibility in a degraded soil and their subsequent exposure to humans through vegetable consumption. Likewise, to investigate the effects of different biochars on the bioaccessible fractions of OCPs in a contaminated soil and their subsequent bioaccumulation into vegetable crops a fourth study was conducted. Four different biochars, derived from sewage sludge, soybean straw, rice straw and peanut shells were applied to a pesticide-contaminated soil at 2%, and the resulting impacts were measured. The results indicated that following biochar additions, the bioaccessible fractions of OCPs in soil and their accumulation in vegetable crops significantly (p<0.01) reduced, as compared to control. Risk assessment showed that biochar amendments markedly (p<0.01) decreased the hazard quotient (HQ) indices and the incremental lifetime cancer (ILCR) values for OCPs associated with the consumption of vegetable crops. From the results of the present studies it is concluded that the application of biochar could play a promising role in enhancing microbial abundance, reducing accessibility, restricting bioaccumulation of organochlorine pesticides in vegetables and decreasing their associated human health risk.