معاشرے کی تعمیر وترقی میں طلباء کا کردار
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
معزز سامعین اور میرے ہم مکتب شاہینو!آج مجھے جس موضوع پر لب کشائی کرنی ہے وہ ہے:’’معاشرے کی تعمیر وترقی میں طلباء کا کردار ‘‘
جنابِ صدر!
طالب علم معاشرے کا ایک اہم جزو ہے، ایک اہم حصہ ہے، معاشرے کی تسبیح کا ایک اہم دانہ ہے، ایک اہم شمارہے، طالب علم کا وجود گھر کے لیے، خاندان کے لیے، معاشرے کے لیے، ملک وقوم کے لیے ریڑھ کی ہڈی کی حیثیت رکھتا ہے۔ وہ معاشرہ جس میں طالب علم کا کوئی کردار نہ ہو وہ حقیقت میں معاشرہ کہلانے کا حق دار نہیں ہے۔
صاحبِ صدر!
ایک ہونہار طالب علم جب علمی درسگاہ کے زیور سے مزیّن اور مرصعّ ہو کر خانگی ، معاشرتی، سیاسی اور قومی ماحول میں قدم رکھتا ہے تو اس کا وجود پورے ماحول کو متاثر کرتا ہے، اس کی گفتگو، اس کی نشست و برخاست ، اس کا قیام وقعود معیاری ہوتا ہے، اس کا اندازِ جہاں بانی منفرد اور یکتا ہوتا ہے، اس نے دورانِ تدریس صحت مند اور مفید نصاب کے اوراق اسود کی ورق گردانی کی ہوتی ہے۔
جنابِ صدر!
اس نے اگر منافقت کا باب پڑھا ہوتا ہے تو ریاکاری اور منافقت سے دور رہ کراپنی زندگی گزارتا ہے ،گل سر سبنر کی طرح مضافاتی علاقے کو معطر رکھتا ہے، جو تعلیمی ادارے میں پڑھتا ہے اس پر من وعن عمل کرتا ہے، اس کی زندگی عوام النّاس کے لیے ایک نعمت غیر مترقبہ ہوتی ہے۔
معزز سامعین!
ایک ذی فہم و فراست اور ذی شعور طالب علم ،علم و دانش کے نشتر سے معاشرے کے وجود سے جہالت، نفرت، بغض، حسد، ریا کاری ،نمود ونمائش، اقرباء پروری...
The enlightened and moderated teachings of Islam empowered every one of the human society, specially the woman who used to be much oppressed in all civilizations of the world before emergence of Islam. Islam gave them an elevated status in all over the world in the status of mother, sisters, daughter and wife. It declared null and void the ignorance rules against them and, prohibited their sexual exploitation. Moreover, Islam gave a regular system of nikkah and marriages for women. The holy Prophet peace be upon him declared nikkah and marriage as his Sunnah and kept its procedure very simple. Furthermore, he described marriage as a gigantic source of achieving chastity, but today in Pakistan the marriages have been made very complex and costly because of the unIslamic customs and traditions. Those unIslamic customs became the part and parcel of the Pakistani marriages which not only made nikkah and marriage a difficult task but also devastated the economic, social and the religious life of Muslims. The Pakistani marriages are conducted with such customs of Mehndi, big congregations: Bharat, beating drums and singing songs. The article briefly discusses status of mirages in the pre Islamic era, Islamic concept and importance of nikkah and the new customs practiced in Pakistani marriages and their economic, social and religious impacts by best use of old and new resources.
Histone proteins wrap DNA around in small globular entities commonly known as nucleosomes. The post translational modifications to the histone tails are referred as histone modifications (HMs). The regulation of DNA in order to access the transcription machinery is epigenetically programmed by specific DNA and chromatin covalent modifications. HMs could either be present or absent at particular genomic loci and the combinatorial patterns of the specific modifications being addressed as ‘histone codes’, are believed to co-regulate significant biological processes. Regions defined by combinatorial patterns of marks can be referred to as chromatin states. Chromatin states associated with genomic locations correlate with specific functional elements as enhancers, transcription start sites, which can be exclusively inferred from successive combinations of chromatin marks in their contiguous locations. Biologically significant combinatorics of epigenetic modifications and their subsequent functional interplay are still mostly unrevealed. We aimed to use ChIP-Seq data of Histone modifications at different genomic loci to highlight the unbiased genomic grouping and to decode the complex biological network of HMs in association with other chromatin players in defining various chromatin states. We used different tools and techniques to accomplish our task. Complex biological networks underlying the hidden chromatin states were revealed via merging machine learning and graph theory existing approaches. Histone modification efficient and simple combinatorics was studied at a global and local scale by developing and implementing a clustering and biclustering tool. Results have been compared with the existing approaches. Meanwhile a simple and efficient computational methodology for efficient chromatin states identification for ChromHMM (HMM based chromatin segmentation) has also been developed by utilizing Hidden Markov Models components. As a result of above study we revealed the role of various factors in maintaining the chromatin state connectivity via focusing chromatin state networks. Our studies highlighted the minimum dominating nodes set and various hubs in chromatin state networks focusing their interaction patterns. Along with we developed and tested a clustering tool ChromClust and a biclustering tool ChromBiSim to highlight histone combinatorics in binarized signal data in an efficient and interactive way. ChromClust operates at global level while ChromBiSim mines local patterns of histone modifications associations. We conclude that epigenomic landscape is portrayed as interplay of various factors including histone combinations, transcription factors, chromatin modifiers and most importantly the underlying DNA motifs. Each chromatin state has a specific set of these factors which interact with each other to mark that state hence creating the whole chromatin states network.