فراقؔ گورکھپوری
آج کل رگھوپتی سہائے فراق گورکھپوری پر بھی ماتم بپا ہے وہ اس دار فانی سے رخصت ہوئے تو اپنے ساتھ اردو شاعری کی بہت سی رعنائیاں اور جلوہ سامانیاں بھی ساتھ لیتے گئے، فانیؔ، اصغرؔ، جگرؔ اور حسرتؔ کے بعد اردو شاعری کے لال قلعہ کے تخت طاؤس پر بیٹھ کر وہی شاہجہانی کرتے رہے، زبان کی زور آوری، فن کی ہمہ گیری، احساسِ جمال کی مرقع آرائی، رومانیت اور کلاسکیت کی ہم آہنگی غزل گوئی کی آئندہ ساخت و پرداخت میں رہبری، کیفیت و حلاوت کی رنگ آمیزی اور اردو زبان کی بے پناہ محبت کی فراوانی میں وہ یگانۂ روزگار رہے، وہ خود کہہ گئے ہیں:
کچھ درد دے گیا ہوں زمانے کو اے فراقؔ
یہ سوچ کر کہ بعد میں یہ کام آئیں گے
(صباح الدین عبدالرحمن، اپریل ۱۹۸۲ء)
One of the main features of the property that Islam does not allow the wealth is concentrated around few peoples; any group or class of society, but according to Islamic point of view money should be in circulation so that poor class of the society could enjoy this blessing from Almighty Allah. Zakat Distribution System is a system of fair procedure for this world by Islam; if it is implemented with true spirit of Islam it can end poverty from the society. Islam obligate rich people of the society to distribute Zakat from their wealth amongst poor people however Islam has ordered not to receiver Zakat more than their needs so that it could be distribute to other poor people of the society. Zakat is an important and has significance in Islam. Islamic law imposed the duty on the Islamic government to collect Zakat from the rich and distribute it to the poor of the society, which caused not only undermined the dignity of the poor. Islamic law imposed the duty on Islamic government to take steps of receiving Zakat. If the government imposed the proper procedures in current banks and other financial institutions to receive Zakat from the rich people of the society and distribute it amongst the poor of the society than it could help to get rid of poverty from the society and it also help for the stability of the economy of any Country?
Phytochemical Analysis and Plant Mediated Nanoparticles Synthesis from Quercus Incana Traditional medicines play significant role as healers, in addition to the synthetic drugs, for different diseases. Plants form a significant part of traditional healing and hence, Quercus incana was chosen for nanoparticles synthesis, biological screening and phytochemical analysis to determine a scientific basis for the traditional use of this plant. The phytochemical screening was carried out using column chromatography (CC) followed by thin layer chromatography (TLC), identification and structure elucidation of pure compounds were done by using spectroscopic and spectrometric techniques (1D and 2D-NMR, IR, UV, Mass). Through phytochemical analysis, fourteen compounds were isolated, among them four compounds (decane-1, 1,4-triol [1], 4-hydroxy-3-(hydroxymethyl) pentanoic acid [2], 2-(4-hydroxybutan-2-yl)-5-methoxyphenol [3], and 3-(2-hydroxy-4 methoxyphenyl) butane-1, 1-diol) [4] were new rare class of aliphatic alcohols and acids. Along these new compounds ten known compounds (Cirsimaritian [5], Eupatorin [6], b-amyrin [7], Betulin [8], Ursolic Acid [9], 3 β-hydroxy-30-Norlupan-20-one[10], 12-Oleanen-3yl acetate [11], β-Sitosteryl-D-glycoside [12], 1-Triacontanol [13], and 4-methoxy-1-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile) [14], were isolated for the first time from Quercus incana except Ursolic Acid. Small sized, polydispersed gold nanoparticles were synthesized using all fractions of Quercus incana (n-hexane, chloroform, ethyl acetate, n-butanol, aqueous fraction) and isolated compound (b-amyrin). 4-Methoxy-1-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile was used for the synthesis of monodispersed silver nanoparticles. Biological screening of extracts, nanoparticles and pure compounds showed tremendous results. All fractions of Quercus incana were analyzed for antioxidant activity, nitric oxide scavenging activity, total phenolic content and antimicrobial potential. Among all fractions, ethyl acetate and n-butanol fractions showed immense biological activities as these fractions may contain polyhydroxy compounds which contribute to the enhancement of activities. Synthesized nanoparticles were screened for antibacterial activity and it was found that extract xi loaded nanoparticles may be used as antibacterial agents by comparing it with crude extract. Crude extract was found inactive at low concentration whereas nanoparticles showed good activity against human pathogens. The unique properties of silver and gold nanoparticles have stimulated the increasing interest in the application of nanoparticles in interfacing biological recognition events with signal transduction and in designing biosensing devices exhibiting novel functions. The recognition behavior of nanoparticles were explored with different drugs and results showed that only Ag-NPs (4-methoxy-1-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile) had biosensing ability towards cephalexin. Isolated compounds were screened for anti-biofilm, cytotoxic and anticancer activity. Eupatorin, Cirsimaritin and β-Sitosteryl-D-glycoside showed good anti-biofilm activity which explored the medicinal use of these compounds in pharmaceutics as an anti-biofilm agent. A preliminary screening of natural product compounds was carried out against NCI-H460 (Non-Small Cell Lung Carcinoma) cell line. The compounds; 12-Oleanen-3yl acetate, Betulin, Eupatorin, and Cirsimaritin showed good anticancer activity. The compound, 12-Oleanen-3yl acetate was found more active anticancer agent against NCI-H460 cell line. Similarly, Cirsimaritin, 12-Oleanen-3yl acetate and Betulin showed good cytotoxic activity against NIH-3t3 (Normal Fibroblast) cell line.