دولت ہے جس کے پاس وہی باکمال ہے
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
معزز اسا تذہ کرام اور میرے ہم وطن ساتھیو!
آج مجھے جس موضوع پر لب کشائی کا موقع مل رہا ہے وہ ہے:’’دولت ہے جس کے پاس وہی با کمال ہے ‘‘
صدرِذی وقار!
ہر انسان خواہ غریب ہو یا امیر ہو، خواہ وہ چیتھڑ وں میں ملبوس ہو یا اس نے خلعتِ فاخرہ زیب تن کی ہو، خواہ وہ سیاہ فام ہو یا سرخ رو ہو، خواہ اس کا قد چھوٹا ہو یا مناسب قد و قامت کا مالک، ہر ایک کو اشتیاق ہے کہ وہ کمال حاصل کرے ، اور اعلیٰ سے اعلیٰ مراتب پر فائز ہوجائے ،ترقی کے مدارج طے کرتا ہوا ثریّا تک پہنچ جائے۔
کسبِ کمال کُن کہ عزیز جہاں شوی!
جنابِ صدر!
معلم کا کمال یہ ہے کہ تدریسی میدان کا شاہسوار ہو،زیرِتعلیم طلباء کی رہنمائی کے لیے مہارت تامہ کا حامل ہو، اپنے مضمون پر مکمل دسترس رکھتا ہو، اس کا ہر سال رزلٹ %100 رہتا ہو، اُس مدرسہ کی نظر میں کامیاب مدرس ہو، خصائل صالحہ کا مجسمہ ہو، تدریسی مہارتوں کے استعمال میں اُسے ید ِطولیٰ حاصل ہو۔
جنابِ والا!
خطیب کا کمال یہ ہے کہ اس کا خطبہ معیاری ہو۔ فرقہ واریت سے پاک ہو، اس کی بیان کردہ روایات حشوو زواید سے پاک ہوں۔ اس کی زبان میں روانی ہو، اور حسنِ صورت کے ساتھ ساتھ حسنِ سیرت کا بھی مالک ہو۔ اس کے پر تاثیر بیان سے تمام سامعین برابرمتمتع ہوں۔
صدرِمحترم!
معلم کمال کی بلندیوں کو چھو سکتا ہے ،مقنن کا طائرکمال فضاء کی بلندیوں میں پرواز کرسکتا ہے۔ خطیب کی ترقی و عروج کی عندلیب گلشن کمال و مراتب رفیعہ میں مسحورکن نغمے آلاپ...
The first main objective of Maqasid I Shari`ah is the completion of human’s necessity; in which protection of progeny (nasl) is the foremost purpose. The preservation of lineage is greatly emphasized by the Islamic Shariah and the Cairo declaration of human rights in Islam also supported the protection of lineage in Islam. All the articles of CDHRI covered the five basic human rights mentioned in Maqasid I Shariah. The research is focused on delineating the concept of protection of lineage as one of the main objective of Shariah and it is supported by evidences from Cairo Declaration of Human Rights in Islam along with Quranic verses and traditions of the Holy Prophet (S.A.W). The aspects covered in the paper range from discussion of right of progeny as well as equal rights of progeny for male and female; rights of children with the hierarchy of their rights from the stage of fetus, having proper nursing, caring, education and a healthy beginning of life. The comparative analysis based on arguments of Shariah and the CDHRI proves that it is the basic objective of Shariah to protect all fundamental rights and right of progeny has the foremost significance in it.
Helicobacter pylori become a major cause of serious health problems and associated with an immense prevalence worldwide responsible for chronic gastritis and peptic ulcer. Therefore the effectiveness of Nigella sativa seeds against H. pylori was evaluated due to its broad range of pharmacological and antibacterial potential against pathogenic bacteria. The maceration method was followed to obtain crude seed extract (22.6 %) using methanol (90 %). This extract was further partitioned into subsequent fractions by following solvent-solvent extraction method using organic solvents according to their increasing polarity order. The percent yield of the resultant fractions were hexane (29.68 %), dichloromethane (15.6 %), ethyl acetate (1.56 %), butanol (18.75 %) and aqueous (34.37 %). The hexane fraction contained the highest value of total phenolic content (43.23 mg GAE/mL) followed by crude extract (40.88 mg GAE /mL). The total flavonoid content present in aqueous fraction (0.62 mg QE/mL) found higher as compared to the ethyl acetate fraction (0.437 mg QE/mL). The ethyl acetate fraction showed the highest percentage of scavenging activity (63.1 %) at 1000 ppm as compared to the other varying concentrations of studied fractions. Thymoquinone (TQ) was estimated and isolated by HPLC. The crude extract showed significantly higher amount of TQ (42.5 %) followed by present in hexane fraction (27.6 %). The thymoquinone was not detected in butanol fraction. The GC-MS analysis of fractions identified a total number of twenty one bioactive compounds including TQ. The FTIR analysis showed the presence of certain functional groups to the bioactive compounds in each fraction, which highlighted the importance of hexane and ethyl acetate fraction for containing prime antioxidant potential. The H. pylori bacterium was isolated and identified from the biopsy samples of infected patients (H. pylori positive). The in-vitro antibacterial activity was carried out against H. pylori, Klebsiella pneumoniae and Staphylococcus aureus. All the fractions and pure TQ was found active against H. pylori with zone of inhibition diameter (mm) ranged between 5.3 to 16.7 mm with minimum inhibitory concentration (MIC) varied in a range from 256 to 2048 μg/mL. Amongst the studied fraction the ethyl acetate fraction and TQ (256 μg/mL) demonstrated an equal highest inhibitory activity against the tested organisms followed by aqueous fraction (512 μg/mL). The butanol fraction with MIC (2048 μg/mL) remain inactive against all tested isolates. The radiolabelling of TQ (100 %) with technetium (Tc-99m) was achieved by following biodistribution and scintigraphic studies. The in-vitro and in-vivo assays were performed to assess the effectiveness of newly synthesized 99mTc- thymoquinone compound in an induced H. pylori infected mice model. The bioactivity of 99mTc-TQ was tested in an internalization assay demonstrated a promising interaction with muscle cancer cell line. Later on an effective dose of N. sativa seed was also determined through an in-vivo study designed for the treatment of H. pylori positive patients. Among the suggested trial dose rates the amount of 2.5 gram of N. sativa seeds per day had shown a promising inhibitory potential against patient’s recovery (80 %) from H. pylori. Current results provided prospects for the use of N. sativa seeds as a newly dietary supplement. TQ was proved to possess potential against H. pylori and contributed as a natural antimicrobial compound will possibly be used as a substitute for antibiotics.