مولوی عبدالباری
افسوس ہے کہ دارالمصفین کے قدیم اور مخلص خدمت گذار مولوی عبدالباری صاحب ۳۰؍ جون کو وفات پاگئے، ان کی عمر ۹۰ سال سے متجاوز تھی، دارالمصنفین کے ابتدائی دور میں حضرت مولانا سید سلیمان ندویؒ نے انہیں تصحیح اور کتب خانہ کی نگرانی کے کام پر مامور کیا تھا جس کو دو برس پہلے تک وہ انجام دیتے رہے، دارالمصنفین کے عروج کا دور دیکھنے والے اب تنہا وہی رہ گئے تھے، ان کی تعلیم مدرسۃ الاصلاح سرائمیر میں ہوئی تھی اور وہ مولانا امین اصلاحی مدظلہ، کے ہم سبق تھے، دارالمصنفین سے وابستگی کی وجہ سے انہیں مضمون نگاری کا چسکہ لگ گیا تھا، ابو علی اثری اور ابو علی اعظمی کے نام سے مدۃالعمر اخباروں اور رسالوں میں مضامین لکھتے رہے، علامہ شبلیؒ کے بڑے مداح اور سیدصاحب کے نہایت عقیدت مند تھے، ان کا ذکر برابر لطف ولذت سے کرتے تھے ان پر اور مولانا ابو الکلام آزاد پر بے شمار مضامین لکھے، دونوں بزرگوں پر ان کے مضامین کے ایک ایک مجموعے ضیاء اﷲ کھوکھر صاحب (گوجرانوالہ، پاکستان) نے شایع کیا تھا، اپنی خودداری کی وجہ سے کسی کا منت کش ہونا گوارا نہیں کیا اور قناعت پسندی کی بنا پر ایک قلیل مشاہرہ پر پوری زندگی گذار دی، اﷲ تعالیٰ ان کی بشری لغزشوں کو معاف فرمائے اور جنت نعیم میں جگہ دے، آمین۔ (ضیاء الدین اصلاحی، جولائی ۱۹۹۳ء)
Studies regarding the prevalence of CLABSIs in Pakistan are limited. However, it is known that healthcare-associated infections are a concern in many low- and middle-income countries, including Pakistan. The present study is aimed to identify the relative risk of developing CLABSIs in the hospital care setups of Pakistan. The risk of biases in included studies was assessed using Cochrane tool parameters. Analysis of results revealed a relative risk of getting CLABSIs is 1.78 (p<0.001) among patients admitted in the hospitals for greater than 72 hours. This shows that the chances of getting infected at the central line site were more than 50% among patients admitted to ICUs in Pakistan. It has been concluded that the relative risk of CLABSIs in the integrated healthcare system of Pakistan is high. DOI: https: //doi. Org/10.59564/amrj/01.01/003
In the present workpyrimido[5,4-c]quinoline-2,4(1H,3H)-diones (5-24) were synthesized by two step reaction sequence involving Knoevenagel condensation and Doebner Miller reaction. Compounds (5-24) were availed by fusion of Knoevenagel adducts (5benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione and 5-(3-nitrobenzylidene)pyrimidine2,4,6(1H,3H,5H)-trione) (3a-b) with anilines viz.sulfanilamide, 4-amino-N-(thiazol-2yl)benzenesulfonamide, sulfamethazine, sulfaguanidine, sulfamethoxazole, paminobenzoic acid, p-nitroaniline, 3-nitroaniline, 3-hydroxyaniline, p-phenylaniline, 5amino-2-hydroxybenzoic acid, 3-aminoacetophenone, 4-amino-2-hydroxybenzoic acid, 4aminoacetophenone and 4-chloroaniline (4a-o) in an oil bath at 170-265 oCafforded desired compounds in moderate to good yields (55-74%). All the compounds were tediously characterized. The prepared compounds (5-19) were tested for their in vitro antioxidant activity and at all instances they exhibited excellent activity in comparison to control Ascorbic acid. Compounds (20-24) were selectively screened for in vitro antibacterial and antiviral activities as these compounds has active pharmacophores in the structure. The most active compounds were 23, 21 and 22 having MIC 0.5, 1.25 and 1.75 µg respectively against P. vulgaris where ampicillin (MIC 2.25 µg) was employed as positive control. In case K. pneumonia compound 24 was found most active (MIC 0.1 µg) in comparison to control ampicillin (MIC 1.25 µg). In case of antiviral activity of the synthesized compounds (2024), compound (23) has expressed maximum in ovo antiviral potency against all four viruses (AIVH9N2, NDV, IBDV and IBV) with IC50 (0.001 µM). In case of synthesis of oxepines (38, 38´, 43 and 43´), a multi-step strategy (9 steps) is developed starting from 1-indanone anf finally the more polar compound 38 was dyrolysed to compound (40) to avail above mentioned compounds in respectable overall yield (0.39%).