جناب شیخ احمد علی شوقؔ
نہایت افسوس ہے کہ کہنہ ادیب و شاعر شیخ احمد علی صاحب متخلص بہ شوق نے ۲۷؍ اپریل کو گونڈہ میں انتقال کیا، مرحوم ۱۸۸۲ء اور ۱۸۹۰ء کے درمیان لکھنؤ سے ’’آزاد‘‘ نام کا اخبارنکالتے تھے، جو اس عہد کے معزز و مشہور اخباروں میں تھا اور اس زمانہ کے ادباء کا مظہر خیال تھا اور سرسید کی تحریکات سے کافی ہمدردی رکھتا تھا، کئی چھوٹی چھوٹی مثنویوں کے بھی وہ مصنف تھے، اسیرؔ مرحوم کے وہ شاگرد تھے اور غالباً وہ اس خانوادۂ تربیت کی آخری یادگار باقی تھے، انہیں کے عہد میں اردو کی نئی شاعری کا آغاز ہوا، مرحوم ان قدیم شعراء میں تھے، جنہوں نے اس نئے رنگ کے قبول کرنے میں جھجک نہیں کی۔
ترانۂ شوق کے علاوہ ان کی غالباً آخری مطبوعہ مثنوی عالم خیال کے چار رخ اردو شاعری میں ایک نئی چیز ہے، کاش ان کے احباب و اعزہ ان کے کلام کا مجموعہ شائع کرکے انکی روحانی یادگاروں کو زندہ رکھ سکیں۔ (سید سليمان ندوی، اپریل ۱۹۲۵ء)
White gold is a man-made bright, white and antioxidant compound, made by mixing platinum and palladium in gold or silver, nickel and some copper in gold, and when yellow gold is added to the various metallic compounds above, it turns white. White Gold was invented in the early 19th century, then it was a mixture of platinum and palladium, but nowadays white gold is a mixture of nickel, platinum, palladium and magnesium, while sometimes it contains copper, zinc and silver. It turns white with color. First White Gold was introduced by Germany in 1912 for sale in the market and then by 1920 White Gold gained popularity as an alternative to platinum. Nowadays white gold is more popular, more favored and is more expensive than yellow gold. White gold is actually yellow gold, with addition of various metals it turns to white so it will apply all the rules that Islam has applied to gold and it is not permissible for a Muslim man to wear its ornaments. However, it is permissible for a woman to wear all kinds of jewelry and Zakat will be obligatory on the man and woman who have the white gold according to the quantity limit prescribed by the prophet (SAW).
Accelerated research in the field of Co-ordination chemistry has vitalize the scientists world over to consider transition metals as possible powerful agents to enhance the pharmacological activities of different drugs. Additionally, it has been explored that accompaniment of transition metal ions to a drug not only potentiates the already known pharmacological action of the drug but may also be responsible for exhibition of newer activities of the compound unnoticed hitherto. Medicinal inorganic chemistry is flourishing with successful clinical application of many metal complexes. Based on these findings the present work aims at synthesizing various transition metal complexes of some reputable and well practiced pharmacological agents. The drugs included antimicrobial agents, Isoniazid and Pyraziamide, antihypertensive agent, Losartan, antimycotic Fluconazole and oral hypoglycemic agent, Biguanide Metformin. Copper, Nickle, Cobalt, Mangnese, Iron and Cadmium ions were used for complex formation. The structures and characterization of all synthesized complexes were established and characterized by using FTIR, UV-visble, NMR, elemental analysis, AA, SEM and XRD data and their physicochemical properties was done by melting point, color, solubility, conductance and magnetic susceptibility values. The metal complexes of Isoniazid and Pyrazinamide were evaluated for their antimycobacterial activity against Mycobacterium strains resistant to commonly used anti tuberculous agents. Furthermore, all complexes were evaluated for their cytotoxic, antiplatelet and antibacterial activities. Cobalt complex of Pyrazinamide were found active against all resistant tuberculous mycobacterium strains while the Mangnese complex of this drug showed anti mycobacterial activity against two of the strains. All complexes of Isoniazid demonstrated activity against resistant strains of Mycobacterium Tuberculosis, Copper complex of Fluconazole exhibited cytotoxic activity against all four cancer cell lines whereas Cobalt and Iron complexes were cytotoxic against KB-3-1 cancer cell line. Pure Losartan was also found to be cytotoxic against cervical carcinoma cell lines. Contrary to these findings, Biguanide metformin metal complexes were inactive in terms of cytotoxic, antibacterial and antipletelet activities depicting no encouraging results.