مولانا محمد سلمان خاں بھوپالی ندوی مرحوم
ندوۃ العلما کے ایک اور لایق فرزند اور مولانا محمد عمران خاں بھوپالی ندوی مرحوم کے برادر خورد جناب مولانا محمد سلمان خاں ندوی مرحوم کی وفات حسرت آیات کی خبر بہت تاخیر سے ان کے صاحبزادے مولوی حافظ کلیم خاں ندوی کے ایک خط سے ملی، اناﷲ وانا الیہ راجعون۔ وہ دارالعلوم تاج المساجد کے سابق مہتمم تھے، لیکن ان کا سب سے روشن کارنامہ تاج المساجد کی تعمیر نو ہے۔ مولانا محمد عمران خاں ندوی مرحوم نے جس شاہانہ اولوالعزمی سے اس عظیم الشان مسجد کی تعمیر و تکمیل کا خاکہ بنایا تھا اس کو مولانا سلمان خاں صاحب نے حقیقتاً رنگ و روغن عطا کیا، جن لوگوں نے مسجد کی تعمیر و تکمیل میں ان کی شبانہ روز کی محنت، جانفشانی اور لگن دیکھی ہے وہ جانتے ہیں کہ اس تعمیر میں ان کا لہو تک شامل ہوگیا ایک عالم کی اس معمارانہ اور مہند سانہ مہارت پر بڑے بڑے انجینئر اور آرکی ٹیکٹ بھی حیران رہ گئے، طبعاً وہ نہایت شریف، متین، کم سخن اور مہمان نواز انسان تھے، اپنے تمام بیٹوں کو انھوں نے حفظ قرآن مجید کی دولت سے بہرہ یاب کیا اور سب کوند وہ ہیں تعلیم دلائی، وہ خود بڑے دیندار تھے متعدد بار حج بیت اﷲ کی سعادت حاصل کی۔ اﷲ تعالیٰ ان کی نیکیوں اور دینی خدمات کو قبول کرے اور جنت نعیم میں جگہ عطا فرمائے، آمین۔ ( عمیر الصدیق دریابادی ندوی ، اگست ۱۹۹۱ء)
Occidentals, in antagonism to Islam, propagate that Law of Jinai is too stringent and rigid. For the reason that in Islam, a living human being is stoned to death, his hands and legs are cut into pieces, and that he is hanged. Some of our modern Muslims have been impressed of the same propaganda and are trying to alter the Islamic set of laws; they further misinterpret the laws ordained in this regard. The fact is that every Islamic law, especially the law of Jinai, is in favour of human beings, having such qualities which laws of the other religions lack. For example, Islam has provided clear distinction between Had and penalty. In Islam, the purpose of punishment is to reform and these Hadoods are not enforced unless the doubts are cleared. This comprehensive provisionary role of Islam is over sighted by the occidental Scholars.
Isolation and Characterization of Plant Based Pesticides With the pace of constant population growth, the demand for sufficient and safer food is continuously increasing around the globe. On the other hand, global loss to crops due to pests, diseases and weeds is significantly high, warranting excessive use of pesticides, threatning environmnet and food safety. The most frequently used pesticides are synthetic posing several associated pre and post application problems such as residual toxicity that results in compromising the safety of food and causing insect resistance. An alternative approach may be to utilize plant’s secondary metabolites that plants actually synthesize in their defense against pests and pathogens. The major aim of current research study was, therefore, to identify, isolate, and characterize at biochemical and molecular level the potent insecticidal compounds from plant sources. To achieve this aim, seven plants namely Cinnamomum camphora, Eucalyptus sideroxylon, Isodon rugosus, Boenninghausenia albiflora, Calotropis procera, Daphne mucronata, and Tagetes minuta were selected. The crude and purified extracts of each of these plants were used to screen for their toxic effects against six economically important agricultural pests, each representing a separate insect order; Acyrthosiphon pisum (Hemiptera), Drosophila melanogaster (Diptera), Tribolium castaneum (Coleoptera), Spodoptera exigua (Lepidoptera), Schizaphis graminum (Hemiptera) and Bactrocera zonata (Diptera). Aphids were the most susceptible insects with 100% mortality observed after 24 h for all the plant extracts tested. Further bioassays with lower concentrations of the plant extracts against aphids revealed that the extracts from Isodon rugosus (Lamiaceae) (LC50 36.2 ppm and LC90 102.1 ppm) and Daphne mucronata (Thymelaeaceae) (LC50 126.2 ppm and LC90 197.5 ppm) found out to be the most toxic to aphids, A. pisum. These most toxic and active plant extracts were further fractionated in different solvent fractions on polarity basis and their insecticidal activity was further evaluated. While all fractions showed considerable mortality in aphids, the most active was the butanol fraction from Isodon rugosus with an LC50 of 18 ppm and LC90 of 48.2 ppm. Further bioactivity guided fractionation of the butanol fraction results in isolation of bioactive principle compound that was identified through various spectroscopic techniques as rosmarinic acid with LC50 0.2 ppm and LC90 5.4 ppm. There was no significant difference between LCs of purified rosmarinic acid and of commercial rosmarinic acid. Further, two key genes, hydroxyphenylpyruvate reductase and rosmarinic acid synthase, known to involve in biosynthesis of rosmarinic acid were targeted to clone from Isodon rugosus. Only one of these genes, hydroxyphenylpyruvate reductase was successfully cloned in Isodon rugosus which consequently will open the way to explore all other genes responsible for biosynthesis of rosmarinic acid. The molecular knowledge regarding biosynthetic pathway will help in biotechnological production of rosmarinic acid and to produce aphid resistant plants through genetic engineering approaches. Considering the high mortality rate in aphids to a significantly low concentration of the rosmarinic acid from Isodon rugosus, could be exploited and further developed as a potential eco-friendly plant-based insecticide against sucking insect pests.