Implementation of a National Identity Number-Based Identity Card Policy in Pasangkayu Regency

The policy development mechanism for the national identity number -based electronic ID card software is described in this report. In this analysis, a qualitative procedure was used in conjunction with a case study technique. The total number of informants was 19. Employees from the government who work on the national identity number -based electronic identification card software make up this group. The culture is often used as a source of information in this report. The findings of the study indicate that; Every organ and implementor personnel at every level in every Pasangkayu sub-district office understands and implements national Identity Number -based electronic identification card policy requirements and goals, namely: first, citizens with a identification card condition have the right to get a electronic identification card, which the government is required to promote. Second, get closer to the position where the community resides, in this case the office respective districts, such that the community is not inconvenienced and burdened, must go to the Disdukcapil office in the district capital. Third, since these programs are provided free of charge or at no expense to government, this approach would not impose an economic burden. Fourth, this proposal has little effect on the district's spending schedule. As a result, success policy is essentially an evaluation of how well expectations and policy priorities have been met. As a result, the policy's standards and objectives must be practical and specifically targeted, and any implementation entity (implementor) must be aware of the policy's standards and objectives.

Phytochemical Investigation of Alnus Nitida and Computational Studies of Some Selected Natural Products

Alnus nitida is a medicinally important plant native to western Himalayas. In Pakistan it is distributed in northern areas and found abundantly in Abbottabad and Mansehra districts. Owing to the importance of the plant as a folk medicine, its wide distribution in the area and the fact that very little phytochemical work has been carried out so far on this plant, male flowers of Alnus nitida were selected for our present phytochemical investigation. In this study, we have investigated nine compounds (all new isolates of Alnus nitida) including a new one: close chain diarylheptanoid (2). They have been completely characterized by using optical rotation, ECD, UV, IR, MS, and NMR techniques. Structure of compounds 2 was validated through theoretical studies as well. The new compound 2 as well as known compounds were subjected to anticancer activity (in vitro) against cervical cancer. For this specific site cancer evaluation, HeLa cell lines and BHK-21 cell lines were used. Results showed that these compounds are potent anticancer agents. Some of them showed much higher activity compared to the reference drug, carboplatin. Computational studies have made tremendous achievements in the recent past. Conformational flexibility of dipeptides and correct assignment of isomeric compounds are challenging tasks. In the current work, we have tried to address these challenges. In the first study, the effects of intramolecular basis set superposition error and dispersion in the determination of correct lowest energy conformer of tyrosine glycine dipeptide molecule, by employing different levels of theory (B3LYP, B3LYP-D3, MP2, and M062x), are explained. The study identified the use of the best density functionals for conformationally flexible compounds especially those having aromatic moiety. In the second study, 1H-1H and 13C-1H coupling constants of possible stereoisomers of quinic acid were predicted to provide reliable assignment of chirality and positions of the hydroxy groups for quinic acids isolated from plants or the synthesized quinic acid derivatives. Analogous DFT techniques can be used to study systems similar to quinic acid such as octulosonic acids etc. In conclusion, nine isolated compounds (triterpenoid, flavonoids, open chain diarylheptanoids and close chain diarylheptanoids) with potent anticancer activity as well as conformational analysis of Tyr-Gly dipeptide and distinction of stereoisomers on the basis of coupling constants is a contribution in the field of natural product and computational chemistry.