پنڈت کشن پرشاد کول
پنڈت کشن پرشادکول لکھنؤ کے رہنے والے اور لکھنؤ کی پُرانی تہذیب اور روایات کی بڑی حسین یادگار تھے، اُردو زبان کے نکتہ سنج ونکتہ شناس، بلند پایہ ادیب اور بڑے صحیح الخیال اورنیک دل بزرگ تھے۔اُردو زبان اوراس کے ساتھ وابستہ کلچر اورتہذیب کے ساتھ اُن کوعشق تھا۔ یوپی میں اُردو کو علاقائی زبان بنانے کے لیے دستخطی مہم کی کامیابی زیادہ ترانھیں کی کوششوں کانتیجہ تھی۔اُردو سے متعلق ہرتحریک میں وہ سرگرمی سے حصّہ لیتے تھے۔ چنانچہ وفات سے کچھ دن پہلے ہی انھوں نے بہار میں اردو کانفرنس کی صدارت کی تھی اوراس میں بڑا اچھا خطبہ پڑھا تھا۔ اگرچہ وہ اب خود دنیا میں نہیں ہیں لیکن اپنے کردار وعمل اوراپنے اخلاق کاایک ایسا نقش چھوڑگئے ہیں کہ نئی نسلیں اُن سے بہت کچھ سبق حاصل کرسکتی ہیں۔ [ فروری ۱۹۵۵ء]
Background: Black Cumin/Nigella sativa (NS) which belongs to the botanical family of Ranunculaceae commonly grows in Eastern Europe, the Middle East, and Western Asia. Its prolonged use can produce physiological changes with or without affecting the architecture of different organs like the heart (cardiac remodeling). The data for the cardiovascular benefits of black cumin are not well-established scientifically. Objectives: To determine the direct cardiovascular effects of Nigella Sativa extract on heart rate, cardiac contractility (apical force), ECG, and coronary flow in the normal heart with and without cardiac remodeling. Methods: This experimental study was conducted on forty-two (42) rabbits. These rabbits were divided into seven groups, each comprising six animals (Group I-VI without cardiac remodeling and Group VII with cardiac remodeling). NS was given to these groups in different doses i.e, Group I (NS=10ug), Group II (NS=30ug), Group III (NS=100ug), Group IV (NS=300ug), Group V (NS=3000ug), Group VI (NS=10000ug) and VII (NS=300ug). Radnoti's working heart system was used to determine the effects of NS on heart rate, cardiac contractility (apical Force), ECG, and coronary flow in a normal heart with and without cardiac remodeling. The results were analyzed using SPSS version 28. Results: Results of this study revealed negative chronotropic and positive inotropic effects without ECG changes in the normal heart and with ECG changes in the remodeled heart. Conclusions: Prolonged use of Nigella sativa can lead to disturbed ECG by affecting the conducting tissue.
A huge amount of electrical energy in Pakistan is lost due to inefficient generation and distribution of power. [13] This project aims to address a very specific problem in this regard which is the energy conversion losses in power converters used with systems of renewable energy generation. The main problem that is being looked into is how the efficiency of an Isolated DC-DC Boost Converter can be improved. Addressing this issue helps in making effective use of renewable energy sources which in turn helps in reducing the energy deficit. To improve upon the design of an Isolated DC-DC Boost converter, it is imperative that first an in-depth study of the already existing designs be carried out. A detailed literature review helped in identifying areas that can be worked upon to increase efficiency. The major losses that occur in an isolated converter come from core and copper losses in its high frequency (HF) magnetic components that are the inductor and transformer. Apart from that, MOSFET losses and diode rectifying losses are also quite significant if chosen poorly. Hence, to increase efficiency, the most important part is an optimized design of HF components, careful selection when it comes to MOSFETs and diodes and finally selecting an appropriate converter topology. Increasing efficiency of HF magnetic components needs a rigorous analysis of design methodologies used to implement them. It was identified that some of the main factors involved in that were core material and geometry and its winding methodology.The killer for inductor and transformer are the leakage inductance and AC resistance which occur due to proximity and skin effect. It was identified that the main losses occur due to the winding method and the type of copper winding geometry. After an in-depth study and comparison between different winding types and methods, it was realized that copper foils help in reducing skin-depth effect and interleaving the windings would help in dealing with proximity effect. Interleaving is when primary windings of the transformer are sandwiched between secondary windings. To validate this design, first a theoretical analysis was carried out after which this design was implemented xi and tested in the lab where significantly low AC resistance and leakage inductance was observed.The major challenges in this project in the design phase were to identify methods for inductor and transformer construction. For transformer design, from analysis it wasdecided to implement interleaved windings but it was challenging to understand how the windings will terminate and physically implementing the windings without any gaps in etween. An unexpected challenge during transformer implementation was soldering the winding terminals using a high wattage soldering iron. This was because the solder has to be minimal to avoid any bumps. Another tight spot faced was while procuring material for the project as most of the required components were not available locally and that led to slight delays in the implementation phase. The converter proposed after the design and analysis has a theoretical efficiency of 97%. There can be a huge impact in utilizing renewable energy effectively if a practical use of this converter is carried out. However, to validate this research, the next step would be to implement the proposed device and computing its actual efficiency. Careful and precise implementation of the design can potentially achieve the calculated efficiency because of the design considerations taken into account. This can then be taken forward to local stakeholders such as the Alternate Energy Development Board (AEDB) as using locally designed and implemented converter will have a significant impact on the cost and benefit breakdown of sustainable energy projects being deployed