مہاراجہ سرکرشن پرشاد
پچھلے مہینہ ملک میں کئی افسوس ناک موتیں ہوئی یمین السلطنت مہاراجہ سر کرشن پرشاد جنہوں نے پورے ۳۷ برس تک دکن کے سیاسی و انتظامی معاملات کی سربراہی کی، وفات پائی، ۱۹۰۲ء میں وہ دولت آصفیہ کے پیش کار و صدر اعظم مقرر ہوئے، اور تھوڑے تھوڑے وقفہ کے ساتھ برابر اپنے عہدہ پر فائز رہے، وہ راجہ ٹوڈرمل کی یادگار تھے، اصلی وطن لاہور اور پھر دہلی ہوا، اور یہاں سے آصفجاہ اول کے ساتھ ان کا خاندان دکن کو منتقل ہوا، اور ہمیشہ شاہان آصفیہ کے سیاسی ومالی مہمات میں کار پرداز بنا رہا۔
مہاراجہ سرکشن پرشاد عربی، فارسی اور انگریزی تین زبانوں سے واقف تھے اور تینوں میں باتیں کرتے تھے، علمی مذاق صاف ستھرا تھا، شعر و سخن کا چسکا رکھتے تھے، تصوف میں وحدۃ الوجود کے عقیدہ کے نہایت سخت معتقد اور حامی تھے، اور اسی کو ہندو مسلم اتحاد کا ذریعہ سمجھتے تھے، سرکار رسالتﷺ کی بارگاہ میں بھی کبھی کبھی عقیدت کا اظہار کرتے تھے، ان کی ایک نعت کو یہ شرف حاصل ہے کہ مدینہ منورہ میں مسجد نبویؐ کے پیچھے کتب خانہ شیخ الاسلام کی ایک دیوار پر آویزاں ہے، مرنج و مرنجان، شریف، وضعدار، اورپرانی شریفانہ خصوصیات کی اپنی آپ مثال تھے۔ (سید سلیمان ندوی، جولائی ۱۹۴۰ء)
The Mohkam and Mutashabeh is a renowned terminology of the Quranic Sciences and commentators of the Holy Quran described it in details, according to root words of Mohkam, it means Stopping and perfecting the things, this basic meaning can be seen in all the types and variations of this word. On the other hand we have the word Mutashabeh which root meaning is complication and unclearness. If we discuss both of the words as a terminology of the Quranic sciences, we can define Mohkam as “one which define itself without any other thing” or “one which has no need to be defined by something else” and Mutashabeh is “one which can’t define itself and need to be explained by someone else”. We will move on to discuss both terms in Holy Quran as a terminology to describe its multiple variations in the Holy Quran, its types and further we will discuss that why the Holy Quran contains both terms, in other words, we can say which are the logics and reasons of including Mutashabeh verses in the Holy Quran. In addition, we will mention the point of views of various renowned commentators and fields experts which give us a clear and sound concept about both of the terms.
Three new series of ligands (derived from amino acids) have been synthesized from view point of their structural and biological studies. The first series belongs to amide derivatives of amino acids (A1-A9), second belongs to urea derivatives of amino acids (A10-A18) and the third one belongs to thiourea derivatives of amino acids (A19-A30). Tributyltin(IV) and bismuth(III) derivatives of these ligands have also been prepared in good yields by refluxing the respective ligand with bismuth(III) chloride or tributyltin(IV) chloride in presence of potassium hydroxide in appropriate stoichiometric ratios in dry methanol as solvent. The structure of the synthesized compounds were characterized by elemental analysis, ICP-OES, FT-IR, multinuclear (1H, 13C, 119Sn) NMR spectroscopy and single crystal X-ray diffraction. Based on these results, the synthesis of ligands have been confirmed and the data also suggested that these ligands appeared to coordinate the bismuth and tin centers through the oxygen of carboxylate moiety. The tributyltin(IV) derivatives mostly demonstrate tetrahedral geometry both in solid and solution state. Whereas octahedral geometry was proposed for bismuth(III) complexes both in solid and solution state based on single crystal X-ray analysis, FT-IR and NMR spectroscopy respectively. Finally the biological activity tests such as anti-bacterial, anti-fungal, anti-oxidant, enzyme inhibition and lethality bioassays for majority of the synthesized ligands were carried out and found some encouraging results. All of the synthesized compounds were evaluated for their potential as anti-bacterial and anti-fungal agents against different strains of bacteria and fungi. Both of the tributyltin(IV) and bismuth(III) complexes have shown good to significant anti-bacterial and anti-fungal properties and some of them were found to be more potent than standard drugs available in markeet. It was observed that tributyltin(IV) complexes have shown slightly better activities than bismuth(III) complexes. These results propose that these compounds may be utilized as anti-bacterial and anti-fungal agents in future in the wake of following the medication improvement methodologies. Anti-oxidant potential of these newly synthesized compounds was also evaluated and some of them exhibited significant anti-oxidant activity. viii These compounds were also examined for their α-glucosidase inhibition, urease inhibition and lipoxygenase inhibition activity and some of the compounds showed excellent results in inhibiting these enzymes, even more than the standard drugs. Some compounds from all the series were tested for anti-tubercular activity and show poor activity. They were also assayed for their brine shrimp lethality test and data suggests that the compounds show low toxicity. However the data pertaining to bioassay tests for all the synthesized compounds exhibiting some encouraging results and may be trialed further in drug discovering processes to find out the lead compounds by modifying/altering their structural motifs.