تلوار سے برتر میر اقلم
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
معزز اساتذہ کرام اور میرے ہم مکتب ساتھیو!آج مجھے جس موضوع پر اظہار خیال کرنے کی دعوت دی گئی ہے وہ ہے:’’تلوار سے برتر میرا قلم‘‘
جنابِ عالی!
تلوار کا اس دنیا مافیہا میں اپنا ایک فنکشن ہے ،تلوار سے میدان جنگ میں مجاہد کاوار دیدنی ہوتا ہے، تلوار کا حامل شخص مقابل کی آنکھ میں کھٹکھتاہے تلوار سے لیس اور اس اسلحہ سے مسلح شخص کی اڑان نرالی ہوتی ہے، تلوار کی واقعی ہی ایک تاریخی حیثیت ہے۔
صدرِ ذی وقار!
تلوارگھر میں ہو، گھر سے باہر ہو، تلوار نیام میں ہویا نیام سے باہر ہو،تلوار ایک ہتھیار ہے ،تلوار ایک اوزار ہے ،تلوار ایک اسلحہ ہے۔ تلوار سے منسوب ہرشخص قوی و توانا گردانا جاتا ہے، اس کی ظاہری طاقت متبیّن ہو جاتی ہے ، ظاہری نقاہت کے باوجود اس کاحامل شخص طاقتورسمجھا جا تا ہے۔
جنابِ صدر!
تلوار کی چمک اپنی جگہ لیکن جو کام قلم کر سکتا ہے و ہ تلوار نہیں کر سکتی، تلوار جسم کو گھائل کرتی ہے،قلم روح کو گھائل کرتا ہے، تلوار کا زخم مندمل ہو جاتا ہے لیکن قلم کازخم تا دیر مند مل نہیں ہوتا، تلوار کی کاٹ عارضی ہوتی ہے قلم کی کاٹ دیر پا ہوتی ہے۔
صدرِ ذی وقار!
قلم سے سخت دل کو نرم کیا جا سکتا ہے، قلم سے بسمل کے زخم پر مرہم رکھا جاسکتا ہے، قلم سے مرغ بسمل کی طرح تڑپتے ہوئے شخص کی مسیحائی کی جاسکتی ہے ،قلم سے جاہل کو صاحب علم بنایا جاسکتا ہے، قلم سے گنوار کوعلم و دانش کی مسند پر متمکن کیا جاسکتا ہے۔
جنابِ صدر!
قلم صحافی کے ہاتھ میں ہو تو معاشرے کے حسن میں...
ObjectiveTo compare clinical and functional outcomes and complications of open reduction internal fixation (ORIF) by plating and Ilizarov technique in complex tibial plateau fractures. MethodsThis study is a randomized clinical trial accompanying 56 patients having Schatzker type V and VI tibial plateau fractures. We divided patients into two groups for management. Group I; open reduction internal fixation versus Ilizarov technique (Group II). We conducted at the Orthopedics Department, Jinnah post-graduate medical centre, Karachi, from April-2018 to Oct2020. The endpoint assessed patients’ satisfaction and clinical and functional outcomes up to an 18-month follow-up. ResultsThe aetiology of tibial fracture was mainly road traffic accidents (RTA); 17 (70.9%) in ORIF versus 23 (71.8%) in the Ilizarov group. According to clinical outcomes, excellent extension lag was achieved in 100% of patients in both groups. Most patients had excellent knee flexion, thigh atrophy and instability outcomes (54.1% vs 59.37%, 87.5% vs 81.2% and 83.3% vs 87.5%). The functional outcome assessment was done and recorded for 18 months of follow-up. There was no significant difference in normal walking, stair climbing, squatting, jumping and duck walking between the groups. The overall rate of complications was similar; 11 (45.8%) in ORIF versus 17 (53.12%) in the Illizarov group (p-value 0.78). ConclusionOur study concludes that there is an excellent clinical and functional outcome found in both procedures. DOI: https: //doi. Org/10.59564/amrj/01.01/008
In last two decades vanadium coordination chemistry has grasp the interest of chemists due to its importance from catalysis and medicinal point of view. Vanadium plays significant role in different biological systems, actively serving in vanadium dependent haloperoxidase and nitrogenase enzymes. It also exhibits insulin-mimetic (anti-diabetic) activity. The present study is carried out in order to synthesize new vanadium (V) complexes with N and O donor hydrazide ligands and reveal their biological importance in terms of antioxidant activities and different enzyme inhibition activities. On the basis of spectral, elemental and physical data, synthesized vanadium (V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. In synthesized vanadium (V) complexes hydrazides act as bidentate ligands and are found to be attached with O of C=O and N of NH2, and these attachments are evident from IR and NMR spectra of these complexes. The inhibitory potential of vanadium (V) complexes of hydrazides against oxidative enzymes including xanthine oxidase and lipoxygenase is determined. In addition, non-enzymatic radical scavenging activities of these complexes were also determined. Results show that hydrazide ligands (1-12) and their respective vanadium (V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and lipoxygenase, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. It is interesting that V(V) complexes are more active for all enzymatic and radical scavenging studies reported here except for lipoxygenase enzyme which demonstrates the difference in the interaction of metal complexes with metalloenzymes. Furthermore enzyme inhibition potential of all the synthesized ligands, metal salt and vanadium (V) hydrazide complexes has also evaluated against tyrosinase, urease and carbonic anhydrase enzymes. Results obtained during the course of this study reveal that hydrazide ligands show moderate inhibition against tyrosinase, but found to be inactive against urease and carbonic anhydrase enzymes. Vanadium (V) hydrazide complexes show variable degree i.e. excellent, moderate to weak activity against all of these studied enzymes. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds and demonstrate the difference in the interaction of metal complexes with metalloenzymes. Further pharmacological and toxicological studies are required to evaluate the bioactive vanadium complexes to find out their potential for use as drugs.