مجید احمد تاثیرؔ (۱۹۱۲ئ۔۱۹۸۶ئ) کا اصل نام مجید احمد اورتاثیرؔ تخلص کرتے تھے۔ آپ سیالکوٹ میں پیدا ہوئے ۔ میٹرک مادرِ علمی علامہ اقبال سے پاس کیا۔ ۱۹۳۳ء میں امر تسر کے ایم اے اوکالج کے طالب علم بھی رہے۔ جہاں ان دنوں ڈاکٹر رشید جہاں اور میاں ڈاکٹر محمود الظفر اُستاد تھے۔ مجید تاثیرؔ امر تسر کی ادبی محفلوں میں شعر و شاعری کرتے رہے۔ فیضؔسے ان کے پرانے تعلقات تھے۔طب کی تعلیم کے لیے تاثیر طبیہ کالج دہلی چلے گئے۔ اس زمانے میں نظم کی طرف توجہ ہوئی اور جوش ملیح آبادی سے دوستی ہوئی۔سیالکوٹ میں تاثیر نے بڑے بڑے مشاعرے کروائے۔ جن میں جوشؔ اور جگرؔ جیسے شاعروں کو مدعو کیا گیا۔(۵۶۴)
لاہور آکر تاثیر نے کچھ عرصہ ملازمت بھی کی۔ آپ نے انار کلی میں ہمدرد مطب قائم کیا۔ جو ش ملیح آبادی جب بھی لاہور آتے تھے ان کے ہمراہ جو چند اصحاب موجود رہتے تھے۔ ان میں تاثیر بھی تھے جوش صاحب مجید تاثیر کی رباعیات کی بہت زیادہ تعریف کرتے تھے۔(۵۶۵)
اُن کا شعری مجموعہ ’’رباعیات تاثیر‘‘ الوقار پبلی کیشنز لاہور نے ۲۰۰۰ء میں شائعکیا۔ یہ مجموعہ کلام رباعیات ،رومانی نظموں اور غزلیات پر مشتمل ہے۔ اس مجموعے کے دو سو سات صفحات ہیں۔اس کتاب کے آغا ز میں ڈاکٹر وحید قریشی نے ’’پیشِ لفظ‘‘ احمد ندیم قاسمی نے تعارف’’مجید احمد تاثیر‘‘ ناہید سلمیٰ نے مضمون’’ تجھے اے زندگی لائوں کہاں سے‘‘ ڈاکٹر سید عبداللہ نے تعارف کتاب’’رباعیاتِ تاثیر ‘‘ ڈاکٹر عبادت بریلوی نے تعارف’’رباعیاتِ تاثیر‘‘ اور جوش ملیح آبادی نے ’’تعارف مجید تاثیر ‘‘پیش کیا ہے۔ جوش نے تاثیرؔ کے تعارف کے ساتھ ایک رباعی بھی لکھی ہے۔ جو درج ذیل ہے:
چرخ شعر و ادب کے تارے تم ہو
جوئے قند و شکر کے دھارے تم ہو
رکھو مہ و مہر پر قدم اے تاثیر
شبیر حسن خان...
The Guiding Principles of Preventing Conspiracies Against Islamic State: The Analytical Study of Demolishing of Masjid al-Dirār Now a day the conspiracy against the leading countries of the Islamic world has become a tragedy under a plan. The examples of Iraq, Lebia, Palestine, and Syria are before us and now these kinds of events are also made against Saudi Arab and Pakistan. So, the protection of every country and its state for preventing conspiracies against it in an effective and successful policy should be adopted, in this aspect there is a great deal of leading can be handed. In the field from the life of the Holy Prophet (saw), we can get an effective policy, to solve the important issues of the modern era about the protection of the state. Our Holy Prophet (saw) adopted the arrangements for the protection of Islamic State of Madinah. One such example is the demolishing of Masjid al-Dirār. Which was conspiracy against the Islamic State of Madinah and completion of hypocritic agenda. Many principles of fiqh-us sīrah are drawn from this incident about the state protection. In this article, we discuss the principles of the protection of Islamic State in the light of Masjid al-Dirār incident and Modern National and international laws.
Diabetic Nephropathy (DN) is a major complication of both type 1 and type 2 diabetes and a leading cause of mortality due to End Stage Renal Disease (ESRD) worldwide. This overwhelming clinical problem is also affecting a number of diabetic patients in Pakistan. Several molecular pathways could lead to the development of DN. In this thesis, the role of genes in one classical pathway, the Renin Angiotensin Aldosterone System (RAAS) along with fatty acid metabolism, and cardiovascular related pathways were investigated in type 2 diabetics, nephropathy and ESRD cohorts. The aim was to see the allele and genotype frequency differences of Pakistani, French and UK population. The study is divided into three parts for Pakistani, French and UK cohorts. For Pakistani Punjabi population, 206 subjects mainly from the Faisalabad district were included. The study design comprised of four groups which were analyzed for biochemical and molecular characterization. PCR and PCR-RFLP based genotyping assays followed by Real Time PCR technique (TaqMan Assay) were carried out for the ACE, AGT, CYP11B2 and ACACB genes to identify the genotypes of each group individually, and calculate and compare their genotype frequencies among four groups as well with individual non-genetic parameters in each group. The association of genotypes was analyzed for their correlation with all of the biochemical parameters, as well as with hypertension, family history of diabetes and nephropathy status. The results showed the association of CYP11B2 gene polymorphism (T/C) with diabetes with OR (95%CI, P value) of 3.20 (1.15-8.91, 0.02), and a significant association of ACACB gene polymorphism (G/A) with obesity/BMI (P =0.009) and type 2 diabetes (P=0.02). For French cohorts, one of the genes of fatty acid metabolism pathway i.e. ACACB (G/A) was analyzed in five different cohorts (n=7438) of diabetic patients who were at various stages of nephropathy. The genotypes were compared for ethnic variations as well as association for different parameters. Results showed a significant association (P=0.02) with ESRD. For UK population, the association study of cardiovascular and hypertension related SNPs in LPA, DAB2IP and TLL1 genes with baseline characteristics or disease outcomes in four UK cohorts (n=5602) was performed. Results showed LPA SNPs association with serum Lp(a) levels in one of the cohorts (NPHS-II group), whereas for DAB2IP SNP (rs7025486), the significant association with High Density Lipoprotein levels (P=0.01) and Diastolic Blood Pressure (P=0.03) was observed. From this study, it is suggested that if similar studies are carried out on large number of samples (replication and meta-analysis), it will be helpful in identifying genetic biomarkers for DN on the basis of ethnic variations and devising pharmacogenomics based interventions.