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Home > Phenotypic Analysis and PCR Optimization for Heterochromia Iridis associated with Waardenburg Syndrome

Phenotypic Analysis and PCR Optimization for Heterochromia Iridis associated with Waardenburg Syndrome

Thesis Info

Author

Saaim Asif

Supervisor

Muhammad Imran Shabbir

Department

Department of Biological Sciences

Program

BS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Country

Pakistan

Degree Starting Year

2016

Degree End Year

2020

Viva Year

2020

Thesis Completing Year

2020

Thesis Completion Status

Completed

Subject

Biotechnology

Language

English

Added

2023-09-23 17:02:26

Modified

2023-09-24 18:12:07

ARI ID

1695561127428

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مولاناعبدالسلام ندوی

آہ مولانا عبدالسلام ندوی
تو نظیریؔ نہ فلک آمد وبودی جو مسیح
باز پس رفتی وکس قدر تو نشنافت دریغ
حضرت الاستاذ رحمۃ اﷲ علیہ کا غم ابھی بھولا نہ تھا، مولانا سید مناظر احسن گیلانیؒ کی یاد ابھی بالکل تازہ تھی کہ ایک اور قدیم اور اہم علمی یادگار مٹ گئی اور مولانا عبدالسلام صاحب ندوی نے ۳ اور ۴ اکتوبر کی درمیانی شب کو دفعتہ انتقال کیا، دارالمصنفین کی پرانی بزم علمی کی یہی ایک شمع رہ گئی تھی جس سے اس دور کی یاد قائم تھی، افسوس کہ وہ ابھی گل ہوگئی، مرحوم مولانا شبلی کے شاگرد رشید دارالمصنفین کے پرانے رکن رکین اور اس کے علمی کاموں میں حضرت الاستاذ کے دست راست تھے، ایک زمانہ میں دونوں کا نام ساتھ ساتھ لیا جاتا تھا، وہ دارالمصنفین کے قیام کے ساتھ ہی اس سے وابستہ ہوگئے تھے اور مر کر اس سے جدا ہوئے۔
وہ فطری مصنف و اہل قلم اور ادیب و انشا پرداز تھے، ان کی اس استعداد کا اعتراف مولانا شبلیؒ کو ان کی طالب علمی کے زمانہ سے تھا، اور انھوں نے ان کے ایک کامیاب مصنف بننے کی پیشین گوئی کی تھی، یہ پیشین گوئی پوری ہوئی اور ہندوستان کے نامور مصنفین میں ان کا شمار ہوا، ان کی تصانیف نے دوسروں کو مصنف اور ادیب و انشا پرداز بنادیا اور ملک کا علمی مذاق بنانے میں ان کا بھی حصہ ہے، ان کی قوت اخذ بڑی تیز تھی، سرسری مطالعہ سے کتابوں کا جوہر کھینچ لیتے تھے قلم برداشتہ لکھتے تھے اور اس پر نظرثانی اور حک و اصلاح کی ضرورت بہت کم پیش آتی تھی، ان کا مسودہ اولیٰ ہی مبیضہ ہوتا تھا، قلم کی یہ پختگی کم مصنفین کو نصیب ہوتی ہے، علامہ شبلی کی زندگی ہی میں، الندوہ کے سب اڈیٹر اور اس کے...

المنھج اللغوي في التفسير و تاريخه

The Holy Quran was revealed in Arabic Language, it is, therefore necessary to seek Arabic Diction to gain the direct guidance from it. The companions of Holy Prophetr, Tabeen, and the reverent Imams strictly rebuked those interpreters who interpret the Holy Quran without having command over Arabic Language. The verses of Quran that are clear in comprehension, explicit and easy, do require the source of interpretation as “Arabic Diction”. This method highlights the positive trends to Arabic Diction. But in the matter of ambiguity and resemblance in verses and deduction of Masael, this Diction will be given second priority. Mere Diction and Arabic Socio-Diction may not be titled as most authentic. Diction is not the ‘last word. ’ The very first priority will be given to the verses of Quran, Hadith e Nabvi and Quotations of Companions of Holy Prophetr. The companions themselves were the native Arabs but they used to do consult some Quranic terms with the Holy Prophetr. As time passed, some strayed sects and atheists ignored this positive trend (Tafseer-bil-Mathur), and accustomed a new trend of interpretation of Holy Quran i. E. Depending upon Arabic Diction only so that they may endorse their own thoughts. It was a negative source of interpreting the Holy Quran i. E. Only by Arabic Diction. The present article explores its historical perspectives after evaluating its negative trends. The Motazila sect got this trend nourished. The representing interpretations of Holy Quran of this trend have been analyzed in this article. At the end, Molana Ameen Ahsan Islahi’s approach to Diction and his Tafseer ‘Tadabbur e Quran’ has been evaluated.

Coordination Compounds of Silver and Copper With S- and N-Donor Ligands for Potential Biological Application

This study deals with the complexes of copper and silver with nitrogen and sulphur donor ligands for potentional biological applications. Our main research was focused onthe synthesisof various ligands containing sulphur and nitrogen donor atoms and some commercially available ligands were also used in complexation with different metal ions such as copper and silver. In most of the cases, we got our expected products with no side reactions, for purification of organic derivatives column chromatography was extensively used. Different ligands which contained sulphur and nitrogen donor sites were synthesized and coupled with different metal salts of the above mentioned metals including pallidium and cobalt in few cases. These ligands can be divided into three different groups 1) quinoline based ligands 2) tetrahydroindazole based ligands 3) thiazole based ligands. The quinoline based ligands were synthesized by multistep reactions. All the reactions gave expected products with negligible side reactions. Compounds 1-9 in the following text are quinoline based ligands and their complexes. All the qunoline based complexes were tested for antifungal, antibacterial, antioxidant and enzymes inhibition activities. The best antibacterial agents among quinoline based complexes waspalladium based compound 7. Similarly the best antifungal agent among quinoline based complexes is compound 6. The antioxidant study showed that compound 7 hasthe highest antioxidant activity among quinoline based complexes, against both ABTS and DPPH. Similarly compounds 7 also showed highest enzymes inhibation against AChE and BChE. Two compounds 10 and 11 are ligands containing N and O donor sites, but at ordinary condition, their complexation with a suitable metal ion was not feasible. Compounds 12-16 are indazole complexes of copper and silver and they were checked for their antifungal, antibacterial, antioxidant and enzymes inhibition activities. Compound 12 was found most effective agent against E.coli, compound 13 was efficient against K. Pneumoniaboth exhibiting 16 mm zone of inhibition. Compounds 12 and 13 showed good activity against A. fumegatus. The antioxidant test of the indazole based complexes showed that compound 15 had better anti-oxidant activity, up to 73% (IC50 value 94µg/mL) and was most effective antioxidant among compounds of the series. Similarly in thiazole complexes17-20, the most active against E.coli and K. Pneumonia was compound 17 which exhibited 19 and 14 mm zone of inhibition, respectively. The antifungal test of the thiazole compounds showed that compounds 18 and 19 were comparatively more active against A. fumegatusas compared to other members of the series. In thiazole complexes 18 was better anti-oxidant agent, exhibiting IC50 value 69µg/mL for ABTS and 50µg/mL for DPPH. Compound 19 had low antioxidant activity IC50= 314µg/mL. Compound 20 was very active AChE inhibitor with 77% activity at 1000 µg/mL. Compound 18 inhibited BchEupto 74% (caculated IC50= 147 µg/mL).