Asian Research Thesis Index

Abstract

From the past few decades, multiple drug resistivity problems rise day by day. Drugs
become resistant over microorganisms like bacteria,fungi, algae etc. To overcome
such kinds of resistivity problems researchers have adopted many new ways and
methodologies. From these methodologies, one way is to cap nanoparticles with
different drugs which may replace conventional antibiotics with these stabilized
drugs. Erythromycin stabilized silvernanoparticles (Ery-Ag(0) NPs)werecombined by
using AgNO 3 with the assistance of erythromycin by using a facile method. The
synthesized(Ery-Ag (0) NPs) wasobserved by UV-Vis absorption spectroscopy,
which inveterate the formation of (Ery-Ag(0) NPs)by stimulating the characteristic
surface Plasmon absorption maxima at 400-420nm. While the confirmation of
bonding of specific drug with silver metal exhibited, the formation of silver
nanoparticles was verified by FTIR.X-ray powder diffraction (XRD) confirmed the
crystalline nature of synthesized Ag (0) NPs. The standard condition employed for
the optimization of this experiment. The effects of (Ery-Ag(0) NPs) were checked on
Salmonella typhimurium?(S. typhimurium)and?Aspergillus niger (A. niger).Well
diffusion method was used to check the antimicrobial activity on S.
typhimurium?and?A. niger, and inhibition zone was in mm to check capability of the
capped (Ery-Ag(0) NPs). The results were compared with standard erythromycin. The
antibacterial and antifungal results revealedthat newly synthesized (Ery-Ag(0) NPs)
had aremarkable activity against S. typhimurium and?A. niger.The results could pave
the new ways against multiple drug resistance. The resistance problems caused by
conventional drugs and microbial activities by reduction or degradation methods
show remarkable and efficient outcomes.

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