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The current research work was conducted to examine, the isolation and phylogenetic analysis of Avulavirus-1 (AAvV-1) that affected different avian species, in past this virus is known as Newcastle disease virus (NDV) or Avian paramyxovirus-1 (APMV-1) causing Newcastle disease (ND) in both poultry and non-poultry avian species in Azad Jammu and Kashmir (AJK) during 2017-18. AAvV-1s are distributed worldwide and the global risk of ND and there are some needs of safe and consistent approaches to elucidate its epidemiology. Hence, the aim of this study was to pathotyped and genetically characterized AAvV-1 isolated from diseased and clinically healthy poultry and multiple non-poultry avian species in AJK. Genetic and phylogenetic analysis based on complete fusion gene sequences showed that fifteen AAvV-1 isolates obtained from poultry, ducks and peacock belonged to sub-genotype VIIi. Though, one pigeon-origin AAvV-1 isolates were clustered in sub-genotype VI-g and three in recently designated new sub-genotype VI-m of class II. Interestingly, the AAvV-1 isolates of genotype VI and VII had epidemiological connections with viruses isolated recently from different locations in Pakistan. The pigeon-origin isolates had the following two motifs 112-RRKKRF-117 and 112-RRQRRF-117, while all other isolates possess the polybasic sequence of amino acid 112-RRQKR?F-117 at the cleavage site F, which is an important characteristic of virulent strains. Our findings, together with recent AAvV-1 studies, suggest possible virus interspecies transmission between poultry and non-poultry avian species and the potential for an AAvV-1 epidemic in the future. The viruses are prevalent in AJK, this work highlighted the need for continuous and large-scale surveillance studies to control and eradicate the disease.
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