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Natural dietary modifications are charismatically used as a first line therapy for treating several diseases. The present study was conducted to examine the antihyperlipidemic effect of herbs Psyllium Husk and Moringa oleifera in rabbits fed with high fat diet. A total of (n=30) rabbits were subjected to five treatment groups with (n=6) animals in each group. The Group I-V were kept under different dose administrations. After eight weeks of experimentation, the blood and tissue samples were tested for biochemical and histopathological analysis. Histopathological studies revealed that MO and PH are hepato-protective and nephro-protective as well. The findings were collaborated with the facts that MO and PH exhibited therapeutic properties against serum lipid parameters. The LDL, TC, TG and Glucose levels were suppressed to significant value P=0.05. It was also inferred that MO and PH elevated the concentrations of good cholesterol HDL. It was suggested that both herbs possessed bioactive compounds like antioxidants that are curative and preventive in nature and might be helpful in lowering secondary hyperlipidemia.
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