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Parthenium hysterophorus is of great medicinal importance. It has been used to cure fever, malaria, diarrhea, dysentery, and neurologic disorders. It also has anticancer agents as well. This study evaluates the antidiabetic effects of methanolic extract of all plant parts of Parthenium hysterophorus in diabetic rabbits (alloxan-induced). Twenty-five rabbits were divided into 5 groups (N=5). The group I served as a standard control. Groups II to V were injected with freshly prepared alloxan solution 150mg/kg intraperitoneally to induce diabetes. Glucose levels were checked to ensure hyperglycemia (diabetes). Group II till V received these treatments. Group II: Alloxan 150mg/kg alone; group III: Alloxan + MEPH (50mg/kg); group IV: Alloxan +100mg/kg MEPH (100mg/kg); group V: Alloxan +Glucophage (62.5mg/kg) respectively for a period of 10 days orally via feeding cannula. The safety assessment of these extracts was carried out in rabbits by oral administration with 50mg/kg, 100mg/kg& 150mg/kg body weight daily for7 days. They remained normal at the dose of 50g/kg, 100g/kg whereas, they showed anxiety in their behavior at high dose i.e., 150mg/kg. Changes in the body weight of all animals were recorded on day 1 , 7 st th 4 th and 10 and 10 th days. Short term (1 st , 3 rd , 5 th and7 th hour) and long term (4 th , 7 th th day) hypoglycemic effect were recorded using easy glucometer C 20. All animals were sacrificed on 10 day to isolate the pancreas for histopathological examination. The results showed that Parthenium hysterophorus L. lowers the blood glucose level in all the groups of alloxan-induced diabetic rabbits. However, the swift reduction in blood glucose level with MEPH was comparatively less than the experimental standard drug i.e., Glucophage.The Pancreatic histopathological studies depicted that a high dose of MEPH administration repaired alloxan-induced pancreatic damage. Whereas, Glucophage only reduced blood glucose level as no repair in damaged tissue was observed in the histopathological study of Glucophage treated animals. The study shows that the whole plant of Parthenium hysterophorus L. is very useful for developing effective phytomedicine to treat diabetes mellitus. The present investigation recommends the use of Parthenium hysterophorus as an herbal remedy for diabetes
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