Home
Add
Get on Google Play
Home
> Edit
Add/Update Thesis
Title*
Author's Name*
Supervisor's Name
Abstract
Cancer is the second most lethal disease all over the world after cardiovascular disorders. Many conventional cancer therapies have so far been used for curing various types of cancer but keeping in view their so many side effects, attention has been focused to some alternative drugs at nano-scale level. The main reason of using phyto-fabricated nano-silver particles was its large surface area. Biogenic nanoparticles are gaining importance due to ecofriendly behavior. The main objective of current study was “Evaluation of Nano-silver Derivatives of Selected Botanical Sources for their Anticancer Potential”. In present study, eleven traditionally used medicinal plants (Curcuma longa, Euclayptus camaldulensis, Ziziphus nummularia, Psidium guajava, Momordica charantia, Syzgium cumini, Viola betonicifolia, Mangifera indica, Fagonia indica, Azadiarachata indica and Cassia absus) were collected by various zones of South and North Punjab (Pakistan). Their aqueous extracts were prepared by using leaves of above-mentioned plants to evaluate bio-active (anti-cancer) potential. The most effective plants were subjected to prepare biogenic silver nanoparticles. At first comparative study of simple plant extracts and phytofabricated silver nanoparticles was carried out for different biological activities; anti-oxidant (2,2, -di-phenylpicrylhydrazyl), anti-diabetic, anti-microbial, hemolytic activity and phytochemical studies; total phenolic contents (TPC) and total flavonoid contents (TFC). Furthermore, anti-cancer activity of five plants (Curcuma longa, Momordica charantia, Viola betonicifolia, Fagonia indica and Azadiarachata indica) was evaluated through in vitro MTT assay, whereby silver nanoparticles of C. longa exhibited lowest IC50 value (0.0045mg/ml) and hence was evaluated against breast cancer cell line (MCF-7) and Ovarian cancer cell lines (A2780). ANOVA (mean ± S.D), Minitab software version 16 and Graph Pad prism were used to figure out significant difference between simple plant extracts and their phytofabricated nano-particles.
Subject/Specialization
Language
Program
Faculty/Department's Name
Institute Name
Univeristy Type
Public
Private
Campus (if any)
Institute Affiliation Inforamtion (if any)
City where institute is located
Province
Country
Degree Starting Year
Degree Completion Year
Year of Viva Voce Exam
Thesis Completion Year
Thesis Status
Completed
Incomplete
Number of Pages
Urdu Keywords
English Keywords
Link
Select Category
Religious Studies
Social Sciences & Humanities
Science
Technology
Any other inforamtion you want to share such as Table of Contents, Conclusion.
Your email address*