Home
Add
Get on Google Play
Home
> Edit
Add/Update Thesis
Title*
Author's Name*
Supervisor's Name
Abstract
The work in this dissertation describes the bioassay-guided isolation, and structure elucidation of sixteen compounds isolated from the fruit part of Aristolochia indica Linn. The dichloromethane, and butanolic fractions of the plant material exhibited activities against prostrate (PC-3), and cervical (HeLa) cancer cell lines. The dichloromethane fraction afforded three new compounds, including aristoloquinone (1), aristolocenone (2), and aristoloanoide (3), while the known compounds were identified as dshamirone (4), chrysophanol (5), 4,8-dihydroxy-6-methoxy-2-methylanthraquinone (6), b -sitosterol (7), oleanolic acid (8), ursolic acid (9), 2-(hydroxymethyl)-3 O furaldehyde (10), hydroquinone (11), and 4 -(acetoxy) phenyl acetate (12). The butanolic fraction of the plant yielded three new constituents, aristoloside A (13), aristoloside B (14), and aristoloside C (15), along with a known compound which was identified as butyl 3-O-β- D-glucopyranosyl-(3R), 4-dihydroxy-butanoate (16). The structures of these constituents were elucidated by using modern spectroscopic techniques, including UV, IR, MS, 1D, and 2D-NMR. HO The isolated compounds were tested for their in vitro cytotoxicity against cancer cell lines. Compounds 8, 9, and 11 showed high sensitivity towards the cervical and prostrate cancer cell lines, as compared to the standard drug, doxorubicin. The other natural/ synthetic compounds were also evaluated for their antitumor activity. Among the natural compounds, physalin derivatives showed a potent activity, whereas among synthetic compounds, organotin (IV) carboxylate, and imidazole derivatives exhibited an excellent activity against the cancer cell lines.
Subject/Specialization
Language
Program
Faculty/Department's Name
Institute Name
Univeristy Type
Public
Private
Campus (if any)
Institute Affiliation Inforamtion (if any)
City where institute is located
Province
Country
Degree Starting Year
Degree Completion Year
Year of Viva Voce Exam
Thesis Completion Year
Thesis Status
Completed
Incomplete
Number of Pages
Urdu Keywords
English Keywords
Link
Select Category
Religious Studies
Social Sciences & Humanities
Science
Technology
Any other inforamtion you want to share such as Table of Contents, Conclusion.
Your email address*