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Background: The Laryngeal Mask Airway (LMA) is one of several supra-glottic airway management devices used in anaesthesia. The scope of use of the LMA is progressively expanding to areas previously contraindicated, for instance laparoscopy and prone position surgery. Certain aspects of LMA use remain unsettled. Whether to remove the LMA when a patient is “awake” vs “deep” following anaesthesia is one such area. The manufacturer Ambu® recommends that the AuraOnce™ LMA be removed once the patient is fully awake and protective airway reflexes are active. Despite this, several studies have shown benefit in removal of the LMA while a patient is “deep” (anaesthetized). Current evidence is inconclusive as to which approach is preferable and safer in adults. Primary Objective: To compare the impact of having LMA removal deep versus awake on the occurrence of airway complications following general anaesthesia in spontaneously breathing adult patients using Isoflurane as the sole volatile agent. Secondary Objective: To compare the impact of deep versus awake LMA removal on anaesthesia theatre turn-around time. Primary outcome measure(s): Airway complication(s), defined as; one or more of the following; Airway obstruction requiring airway manipulation; Laryngospasm; Desaturation to 90% or less on pulse oximetry. Secondary outcome measure(s): Time to theatre exit Study Setting: The Aga Khan University Hospital, Nairobi, Kenya. Study Design: A prospective randomized control trial (open). Sample size: A sample size of 116 participants, 58 in each arm. Study population: ASA I and II patients aged 18-65 years scheduled for theatre for low to moderate risk, non-emergent surgery. Procedure: 116 adult patients were randomly assigned to one of two groups. A standard anaesthesia protocol was used for induction and maintenance of anaesthesia. For the deep arm; The LMA was removed at the end of surgery after attaining an end tidal minimum alveolar concentration of Isoflurane of 1.15%. Occurrence of airway complication(s) (One or more of the following; Airway obstruction requiring airway manipulation; Laryngospasm; Desaturation to 90% or less on pulse oximetry) was noted until the subject was fully awake (appropriate response to command) in the post anaesthesia care unit. For the awake arm; The LMA was removed on attaining an end tidal minimum alveolar concentration of Isoflurane of <0.5% and an appropriate response to command or obtaining appropriate response to command irrespective of end tidal concentration. Occurrence of airway complication(s) (One or more of the following; Airway obstruction requiring airway manipulation; Laryngospasm; Desaturation to 90% or less
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