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Advancements in Interstitial Brachytherapy

Thesis Info

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Author

Shahid Bashir Awan

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Physics

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2204

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725439377

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In recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients. The popularity of this modality is due to the fact that five-and ten-year disease control rates using brachytherapy are equal to those of surgery, whereas, the toxicity and side-effects are perceived to be lower. Recently, a true linear source model RadioCoilTM103Pd has been introduced to overcome the shortcomings of traditional ―seed‖ type interstitial prostate brachytherapy implants, such as migration and clumping of the seeds. However, the existing prostate treatment planning systems and TG-43U1 have not been updated to perform dose calculation and parameterization respectively, for implant with linear sources greater than 1.0cm in length. Due to these limitations, the innovative design of RadioCoilTM103Pd could not be fully implemented for clinical applications. In this research, treatment planning aspect of elongated RadioCoilTM103Pd sources is investigated. In addition, accuracy of existing TG-43U1 recommended dosimetric parameters in polar coordinate systems, a modification in radial increment to improve the accuracy and modification of TG-43U1 parameterization in to cylindrical coordinate systems is also investigated. This work resulted in a calculational method and modification in TG-43U1 parameters for accurate dose calculation around elongated sources. Experimental, Thermolumenance Dosimetry TLD and Monte Carlo simulation techniques were employed in this investigation. This work was successfully completed and led to a new Task Group, TG-143 from American Association of Medical Phyicists in Medicine, AAPM, to provide guidelines for clinical application of elongated sources and extend our findings for other elongated sources.
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نیناں دے کشکول بھرے نیں

نیناں دے کشکول بھرے نیں
کہن توں لیکن درد پرے نیں

ہاواں دی انج برف پئی اے
بلدے سینے آن ٹھرے نیں

ربا ! توں تے جانوں ایں ، میں
کیہ جہے ، کیہ جہے دکھ جرے نیں

جنھاں مَیں نوں ڈوب لیا اے
جند سمندر خوب ترے نیں

جنگ تے حاکم جت لئی اے توں
ساڈے جیہڑے لوگ مرے نیں

COMPARISON OF THE LEVEL OF BURNOUT AMONG THE ACADEMIC AND CLINICAL PHYSICAL THERAPISTS

Aims of Study: To compare the level of burnout among the academic and clinical physical therapists. Methodology: A cross sectional study was conducted from August 2019 to January 2020. Data was collected from physical therapists working in the universities and hospitals of Rawalpindi and Islamabad. Data was collected from 278 participants. Maslach burnout inventory scale was used to measure the level of burnout which was analyzed using SPSS statistics 21.  Results: The mean value of emotional exhaustion for clinical physical therapists was 20.02 ± 8.08 and for academic physical therapist was 18.6 ± 6.57 with significant p value (p˂0.05). The mean value for depersonalization for clinical physical therapists was 9.22 ± 5.17 and for academic 9.29 ± 5.07 with significant p value (p˂0.05). The mean value of personal accomplishment for clinical physical therapists and academic physical therapists was 35.43 ± 7.715 and 35.74 ± 6.49 respectively with non-significant p value (p˃0.05). Limitations and Future Implications: It was conducted for specific time period which not record the overall or yearly impact of burnout on participants. So time lapse and longitudinal study should be done. Originality: The clinical physical therapists have increased level of burnout than academic physical therapists. Conclusion: The clinical physical therapists have increased level of burnout than academic physical therapists.

Improved Technique for the Calculation of Heat Transfer in a Thrust Chamber

Advancements in rocket propulsion have been the key factor for the scientific progress especially in space exploration and communication. The continued quest to achieve higher propulsion velocities at low cost still provides the room to the scientists and engineers to work on the development in the design of thrust chamber of a rocket engine. Given the high manufacturing and operational cost of rocket engines, precise knowledge of the chamber dynamics, propellants flow and feed system, heat transfer and structural integrity are important. During operations the thrust chamber experiences high temperatures and pressures, thus a reliable design requires adequate knowledge of the flow and combustion physics inside the chamber. A number of ways have been employed by the researchers to optimize heat transfer and performance of the engine. Generally regenerative cooling along with film cooling are used for safe operation.For small LPREs with small mass flow rates of the coolant, safety of the chamber wall becomes challenging job. Structural integrity can be attained by specific heat transfer rate and efficient combustion will give better performance. Numerical estimation of heat transfer using commercial software may be help for design and mounting instrumentation for experimentation at proper place. However one requires an integrated design tool for designing a thrust chamber with optimal performance ensuring adequate thrust, structural integrity and efficient cooling. For optimization of such a thrust chamber, couple fluid-structure-heat transfer analysis is often complicated and requires huge computational resources using commercial software. The combustion chemistry is often approximated through one dimensional theory. Generally experimental/empirical correlations are used for heat transfer rate calculations or one has to rely on expensive testing to validate structural design and safe operation. However the high cost involved with experimentation and manufacturing of even a small chamber, an integrated tool for optimal design of thrust chamber can be helpful. The optimized geometry can be numerically simulated for confirmation before leading to actual use. The integrated design tool can help in obtaining optimal thrust under given dimensional and flow constrains with adequate heat transfer rates ensuring low design cost. The major aim of this research work was to develop an in-house integrated software tool for the design and optimization of the coolant channel configuration of thrust chamber of a rocket engine. However, the study also includes the experimentation and CFD study for the validation of the tool developed. The developed integrated tool includes seven modules providing optimal performance parameters for a given thrust chamber design. The modules include combustion chemistry, flow dynamics, heat transfer and optimal cooling channels design for a given thrust chamber shape. Here the results obtained from the integrated tool have been verified using own computational fluid dynamics results and experimental data as well as the published results available in the literature. Amongst the important parameters, heat transfer rate within the thrust chamber is key design parameter. Here focus is on the prediction of heat transfer rates and surface temperatures of both coolant and thrust chamber. Thus results for the heat transfer rates and heat transfer coefficients are compared with published results, numerical simulations and experimental data. Further calculations for the optimized coolant geometry have been carried out based on the heat transfer, flow rate and pressure drop across the coolant channel. The results indicate that the predicted geometry offers safe operation of the thrust chamber. The integrated tool developed in this study is intelligent enough to optimize a number of coolant channel flow configurations with different coolants and fuels within a short time.