Search or add a thesis

Advanced Search (Beta)
Home > Design, Synthesis, Characterization and Anti-Inflammatory Studies of Oxa and Thiazole Scaffolds

Design, Synthesis, Characterization and Anti-Inflammatory Studies of Oxa and Thiazole Scaffolds

Thesis Info

Access Option

External Link

Author

Ghani, Ambreen

Program

PhD

Institute

Lahore College for Women University

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12841/1/Ambreen%20Ghani_Chem_2018_LCWU_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676725828531

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


Inflammatory diseases are associated with a number of ailments; these disorders could be life threatening like hepatitis, cancer, trauma injury while some decreases the quality of life such as rheumatism, arthritis, tuberculosis etc. Oxa and thiazoles, having unparalleled share in pharmacological activity of especially anti-inflammatory, have arisen as superb templates in drug discovery. Their unique attributes have instigated synthetic chemists to access their innovative analogues by efficient and viable strategies. Insightful insertion of other heterocyclic cores, bicyclic rings and other active functionalities at appropriate sites has greatly enhanced their diversified bioactivities. This research endeavor is made to synthesize some novel anti-inflammatory agents based on oxa/thiazole via green protocol. Hence synthesis of new derivatives of oxa and thiazoles by novel routes focusing green strategy such as DES mediated preparation were carried out by adopting Hantzsch approach. For this purpose, ketones containing simple alkyl to pretentious alkyl functionalities such as tetrahydrocarbazoles and aryl moieties like phenyl and coumarin were used. Besides this, novel amide and thioamide analogues were also synthesized by functionalizing established bioactive heterocycles at their N position and the second step is annulation of these analogous with a series of bioactive ketones. A series of novel oxa and thiazoles each comprising twenty one compounds were synthesized. All new molecules were screened for in vitro anti-inflammatory potential by HRBC membrane stabilization method. Precursors were also subjected to antiinflammatory screening and only those were employed for the synthesis of oxazole and thiazoles which were found comparatively potent. N N NH 2 X R 1 O CH3 N N X R 1 N H X N R 1 N Oxa/ thiazoles N H R H X 2N N R H X 2N Green / Conv. Precursors Characterization of all of the innovative derivatives was done by analytical techniques like FTIR, 1HNMR and MS and CHNS analyser. Compounds 110, 111, 113d, 113b, 113g, 114a, 114b, 114c, 114f, 115b, 115e, 115f, 116d, 117b, 117c, 118a, 118b were found to possess best anti-inflammatory activity.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

مولوی محمود الحسن

آہـ! مولوی محمودالحسن
اس مہینہ کے معارف کی طباعت ختم ہو رہی تھی کہ یکا یک خبر ملی کہ مولوی محمود الحسن ناظم انجمن تعلیمات دین، اپنے بچوں، عزیزوں اور قدر دانوں کو چھوڑ کراب وہاں ہیں جہاں نیکوں، پاکبازوں، صفاکشوں کو سرور جاودانی اور حیات ابدی ملتی ہے، ان کی دائمی جدائی پر کچھ آنکھیں نمناک اور اشکبار ہوں گی، لیکن انجمن تعلیمات دین کے کارکنوں اور ہمدردوں کی آنکھوں سے خون کے آنسو، بھی جاری ہوں گے تو اس سے ان کی دائمی رحلت کی غم ناکی اور درد ناکی دور نہ ہو سکے گی، ان کی وفات کچھ ایسا ہی جاں گسل سانحہ ہے۔
وہ انجمن تعلیمات دین کے بانیوں میں سے تھے، ۱۹۴۷؁ء کے انقلاب کے بعد چند مردان خدا کی بدولت یہ انجمن قائم ہوئی تو زبان حال سے یہ کہہ رہی تھی:
یہ دور اپنے ابراہیمؑ کی تلاش میں ہے
اس انجمن نے اترپردیش میں جو کام انجام دیے ہیں، وہ مسلمانوں کی ملی تاریخ کا ایک زریں کارنامہ ہے، اس کے ذریعہ سے بے شمار دینی مکاتب قائم ہوئے، جن سے اترپردیش کے مسلمان بچوں کی دینی حمیت اور ایمانی غیرت کے ثبات ویقین کا سامان فراہم ہوا، جناب عدیل عباسی مرحوم نے اس کارواں کے یکہ تاز بن کر جس طرح رجز خوانی کی، اس سے انجمن کا کام بہت آگے بڑھا، ان کے یمین ویسار میں مولوی ظفر احمد صدیقی مرحوم وکیل اور مولوی محمود الحسن رہے، جس سے اس کے کام کو غیر معمولی فروغ ہوا، مصلحت خداوندی سے جناب عدیل عباسی مرحوم اور جناب ظفر احمد صدیقی مرحوم، مولوی محمودالحسن کو تنہا چھوڑ گئے، مگر وہ اس کے لیے عمل پیہم اور یقین محکم بلکہ سوزدروں، درد پنہاں اور روح جاں گسل بنے رہے، وہ کسی مجلس میں بیٹھ جاتے تو معلوم ہوتا کہ انجمن تعلیمات...

HUBUNGAN ANTARA EFIKASI DIRI DAN PERAN GURU DENGAN BELAJAR BERDASAR REGULASI DIRI PADA AKSELERAN

This research is a quantitative approach with the aim at knowing: (1). The relationship between self-efficacy and the role of the teacher by learning based on self-regulation. (2). The contribution given by self-efficacy and the role of teachers in self-regulation based learning. (3). Levels of self-efficacy and the role of teachers in learning based on self-regulation. The subject of this study was acceleration in one of the Public High Schools in Surakarta as many as 115 people. This study is a principled study on population studies. Based on the results and analysis using multiple regression it is known that the correlation coefficient R = 0.375 (p = 0.000: p <0.05), which means that there is a significant relationship between self-efficacy and the role of teachers with self-regulation. The total contribution given by the two independent variables in this study amounted to 14.1%, and for both categorizations the independent variables namely self-efficacy and the role of the teacher were at a high level, and the dependent variable of learning based on self-regulation was at a very high level. Key word: Self-Regulated Learning, Self-Efficacy, The Role of Teachers

A Randomized Control Trial Comparing Train of Four Ratio ≥0. 9 to Clinical Assessment of Return of Neuromuscular Function Before Endotracheal Extubation on Critical Respiratory Events in Adult Patients Undergoing Elective Surgery at the Aga Khan University Hospital, Nairobi

Background: There is increasing evidence that the incidence of postoperative residual paresis after using neuromuscular blockers ranges from 24 to 50% in post anaesthesia care unit and is associated with postoperative complications such as critical respiratory events as evidenced by hypoxia, hypoventilation and upper airway obstruction. Quantitative neuromuscular monitoring (such as the assessment of Train of four (TOF) ratio) and reversal of neuromuscular blockers has been shown to reduce postoperative residual paresis. There are very few outcome studies on effect of residual paresis in Post anaesthesia care unit (PACU). There are no published randomised control trials investigating whether using a TOF ratio ≥0.9 before endotracheal extubation compared to clinical assessment of return of neuromuscular function reduces the incidence of critical respiratory events in PACU. Primary Objective: To determine whether using TOF ratio ≥0.9 compared to clinical assessment of return of neuromuscular function before endotracheal extubation reduces the incidence of critical respiratory events in PACU Secondary objectives: To determine incidence and severity of hypoxia in PACU. To determine incidence of upper airway obstruction in PACU Study Design: Randomised, prospective, double blinded control trial Setting: Operating theatres of the Aga Khan University hospital Nairobi Population: Adults, aged 18-65 years ASA physical status I and II undergoing elective surgery under general anaesthesia. Sample size: 168 patients randomised to TOF ratio group and clinical assessment group, 84 per group. Methods: Patients requiring general anaesthesia for elective surgery with cisatracurium as the muscle relaxant were randomised into 2 groups using computer generated numbers. Group 1 were patients who required a TOF ratio of ≥0.9 before extubation. Group 2 patients were extubated based on clinical assessment of return of adequate neuromuscular function by the anaesthetist as is the standard of practice at the Aga Khan University hospital Nairobi. General anaesthesia was standardised in both groups. Both the investigators and patients were blinded during the study. Once the patient was transferred to PACU, oxygen saturation (SP02), respiratory rate and any signs of upper airway obstruction as demonstrated by stridor, laryngospasms or requirement of any airway manipulation was recorded for the first 30 minutes. Duration of anaesthesia and surgery was also recorded. Patient demographics were recorded and analysed. vii Results: There was no statistical difference between the 2 groups in terms of patient demographics, duration of surgery and anaesthesia and duration since last muscle relaxant was given. In terms of hypoxia on arrival in PACU, the incidence of