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Home > Isolation and Characterization of Alkaloids: Study of Ddelphinium Chitralense and Related Medicinal Plants.

Isolation and Characterization of Alkaloids: Study of Ddelphinium Chitralense and Related Medicinal Plants.

Thesis Info

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Author

Shujaat Ahmad

Program

PhD

Institute

University of Malakand

City

Malakand

Province

KPK

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12945/1/Shujaat_Ahmad_Chemistry_HSR_2017_UoM_Malakand_15.06.2017.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726528813

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The present Ph.D thesis describes the phytochemical and biological exploration of two species belong to family Ranunculaceae of District Dir (U), Khyber Pakhtunkhwa Pakistan. The main goal of our research was the isolation, structure elucidation, selective AChE and BChE enzyme inhibition of C19 and C20 diterpene alkaloids from the basic chloroform soluble fraction of D. chitralense and D. denudatum Wall. Seven new compounds; Chitralinine-A (1), Chitralinine-B (2), Chitralinine-C (3), Chitraline-A (4), Chitraline-B (5), Chitraline-C (6), Chitraline-D (7) and two known, Ajaconine (10) and Delectinine (11) have been isolated from the aerial part of D. chitralense. Two new Jadwarine-A (8) and Jadwarine-B (9) and one known dihydropentagynine (12) have been isolated for the first time from the aerial parts of D. denudatum Wall. All the isolated compounds (1-12) were characterized by various spectroscopic techniques and screened for enzyme inhibition activities (AChE & BChE). The isolated compounds were found to be potent AChE and BChE inhibitors. Our present findings indicate the interest of C19 and C20 diterpenoids as potent AChE and BChE inhibitors present in the investigated two delphinium species. They may contribute towards naturally accessible inhibitors used for the treatment of Alzheimer’s disease.
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نواب شوکت خاں

نواب شوکت خاں
دوسرا حادثہ باغپت کے نوجوان رئیس نواب شوکت خاں کی وفات ہے ان کو اﷲ تعالیٰ نے امتیازی و جاہت کے ساتھ دینداری کی دولت سے بھی نوازا تھا، چنانچہ حاجی اور حافظ بھی تھے جس کی مثال جدید تعلیم یافتہ نوجوان رئیسوں میں مشکل سے ملے گی، اسمبلی کے ممبر بھی رہ چکے تھے، سٹی سنٹرل وقف بورڈ کے صدر تھے، اس تعلق سے کئی سال ان سے سابقہ رہا، طبعاً نہایت شریف اور مہذب و متین تھے، عمر چالیس بیالیس سال سے زیادہ نہ تھی، اﷲ تعالیٰ اس نوجوان اور دیندار رئیس کی مغفرت فرمائے۔
(شاہ معین الدین ندوی، فروری ۱۹۶۹ء)

پاکستان کے مشترکہ خاندانی نظام میں رہائش سے متعلقہ مسائل اور ان کا حل (اسلامی تعلیمات کی روشنی میں ایک جائزہ) Issues of Accommodation in the joint family system of Pakistan and their solution (An analytical study in the context of the Islamic teachings)

A family is the fundamental unit of society. Every society has the presence of a family. The start of a family's life is entirely dependent on matters of co. human relations. All such human relationships are entrenched in islamic sharia as a sacred bond of nikah, in which a husband and wife become a part of the world in the form of a family's collective result. Husband and wife are the most fundamental pillars of society, and their affection and companionship provides a source of stability for them and also a refuge for coming generations.A  family consist of husband ,wife and their children . The family life is begins with marriage, after marriage every woman wants to have her own separate home where all the requirements of privacy are met. Islam has placed the entire responsibility of livelihood on men..But in our society there are two types of family system joint and separate family system. In Pakistan The joint family system is prevalent. The people of the subcontinent are not only adopting this system but they are  also feel proud of it . In the present article the joint family  system has facing many challenges. One of them is accommodation. In this article will focus on  what is the basic concept of accommodation in joint family systems and its solution in Islami teachings. It is critical for the husband and wife to have a home where no one can  interfere on their personal matters. This interference is very much in our society.Which husband and wife facing many  problems. And due to this conditions, the relationship of husband and wife is also affected. Key Words: Joint family system, Issues of Accommodation, Pakistani society, Islamic teachings.

Theoretical Studies of Strongly Correlated Lanthanide Intermetallics Lnx3 X=In, Sn

In this thesis the structural, elastic and electronic properties as well as electric eld gradient of the strongly correlated intermetallics LnX3 (Ln = La-Gd, X = In, Sn) have been investigated by using the full potential linearized augmented plane wave plus local orbital (FP-LAPW+lo) method within the framework of density functional theory. The structural properties of these compounds are calculated by LDA, GGA, meta-GGA, WC, B3PW91, LDA+U and GGA+U schemes. The calculated lattice parameters are found consistent with the available experimental results. Our results show contraction of lattice constant along the series and the divalent state of Eu is also veri ed. The itinerant and localized behavior of electrons in f -states of these compounds is also discussed. These compounds have 4f orbitals and hence strong electron-electron correlation e ect is expected, therefore, the electronic properties are also calculated with the Hubbard potential U (GGA + U and LDA + U) and the e ect of Hubbard potential on the density of states is discussed in details. The relativistic e ects are also considered by including the spin-orbit coupling (SOC). The spin-orbit coupling predict the correct electronic properties and also reveals the splitting of 4f states of the rare-earth elements. It a ects the band structures of the compounds and induces non-degeneracies in some degenerate states in the vicinity of the Fermi level. Furthermore, the SOC e ect increases from left to right in the lanthanide series in the LnIn3 and LnSn3, which shows interesting nature of SOC e ect in the periodic table. The elastic constants of these compounds are also calculated. Our calculated values for the elastic constants of the compounds are closer with the available experimental values as compared to the other theoretical results. The mechanical properties for the compounds under studies such as shear iii modulus, bulk modulus, Young''s modulus, Kleinman parameters, anisotropic ratio, Poisson''s ratio, Lame''s coe cients are also determined . The Cauchy pressure and B/G ratio are also investigated to evaluated the ductile and brittle nature of LnIn3 and LnSn3 compounds. The Sound velocities for shear and longitudinal waves, and Debye temperature also explored on the basis of mechanical properties. The Electriceld gradients (EFG) are also calculated for the rare-earth intermetallics LnIn3 and LnSn3 (Ln = La, Ce, Pr and Nd) using the GGA, GGA + U, as well as GGA + SOC. Our results show that the EFGs calculated by GGA+U approach are in better agreement with the available experimental values of the M ossbauer spectroscopy as compared to the other theoretical schemes. Our results show nonzero EFGs at rare-earth sites in the AFM phase. The present research will add some theoretical understanding of these materials and will alsoll the gap about some of the physical properties of these compounds in literature.