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Home > Isolation, Modification, Characterization, Pharmaceutical Applications of Hydrogel from Seeds of Cydonia Oblanga

Isolation, Modification, Characterization, Pharmaceutical Applications of Hydrogel from Seeds of Cydonia Oblanga

Thesis Info

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Author

Ashraf, Muhammad Umer

Program

PhD

Institute

University of Sargodha

City

Sargodha

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Pharmaceutics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12318/1/Muhammad%20Umer%20Ashraf.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726553616

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Extraction of Quince hydrogel (QH) was accomplished from seeds of Cydonia oblonga M (Quince) by hot water extraction method. Characterization of QH was accomplished by using Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and thermogravimetic analysis (TGA). Swelling of QH was carried out in deionized water, buffer solutions of pH 1.2, 6.8 and 7.4 by using gravimetric analysis, inferring that QH showed high swelling capacity in deionized water and buffer solutions of pH 7.4 and 6.8 while minor swelling was noticed in acidic buffer of pH 1.2, indicating QH as a potential biomaterial for fabrication of targeted drug delivery. Kinetic models were also applied to the swelling data acquired from swelling studies. It was concluded that swelling of QH in deionized water and phosphate buffers of pH 6.8 and 7.4 followed second order swelling kinetics. Responsiveness of QH to concentration of electrolytes was also ascertained by carrying out swelling of QH in different molar concentrations of NaCl and KCl solutions (0.1, 0.2, 0.3, 0.4, 0.5, 1.0 and 2.0 M). The QH was deduced to be responsive to concentration of electrolytes, showing a decrease in swelling capacity with increasing molar concentration of electrolytes. Swelling deswelling (on-off) response of QH was also evaluated in water and ethanol, water and normal saline and phosphate buffer of pH 7.4 and acidic buffer of pH 1.2. When water swollen QH was immersed into saline and ethanol, deswelling of QH was noticed however, deswelling in ethanol was abrupt as compared to deswelling in saline solution. Similar swelling deswelling response was noticed in phosphate buffer of pH 7.4 and acidic buffer of pH 1.2. These findings prove QH to be stimuli sensitive biomaterial with potential to be used in developing stimuli responsive drug delivery system.
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راجیو گاندھی

راجیو گاندھی
وسط مدتی انتخابات کے دوران میں مدراس کے ایک انتخابی جلسہ میں تقریر کے پروگرام سے کچھ دیر پہلے ہی ہندوستان کے سابق وزیراعظم اور انڈین نیشنل کانگریس کے صدر جناب راجیوگاندھی ایک بم دھماکے میں لُقمۂ اجل ہوگئے۔
اس وسط مدتی انتخاب کے بارے میں جہاندیدہ دانشورانِ ملک اور خودمقتول ...راجیوگاندھی یہ خدشہ ورائے ظاہر کررہے تھے کہ اس وسط مدتی انتخاب میں زبردست تشدّد کاامکان نظرآرہا ہے ۔یہ کس کومعلوم تھاکہ جس تشدّدکے امکان کااظہار کیاجارہاہے وہ ملک کی اس عظیم ہستی ہی کو اپنی منحوس لپیٹ میں لے لے گا۔مگرانہونی ہوکررہی اورملک اایک ایسے رہنما سے محروم ہوگیا جو دورِ حاضر کاہیرو تھا اور مستقبل کی روشن قندیل، اور جس سے ملک و کوبڑی بڑی امیدیں وابستہ تھیں۔
جناب راجیو گاندھی کے حادثۂ قتل میں کس پارٹی، کس گروہ ،کس ملک یا کس فرد کاہاتھ ہے اس کے بارے میں کچھ کہنا قبل از وقت ہے۔ابھی تک کسی نے اس کی ذمہ داری قبول نہیں کی ہے۔عام طور پرایل ۔ٹی۔ٹی دہشت پسندوں پرشک ظاہر کیا جارہا ہے۔اوراس کے لیے اخبارات کی اطلاع کے مطابق کچھ ٹھوس ثبوت بھی جائے واردات سے مِلے ہیں۔ جو عورت اپنے جسم پر بم باندھ و لپیٹ کر خودبھی ہلاک ہوئی ہے اور جناب راجیوگاندھی کے ساتھ اوردوسرے تیرہ افراد کوہلاک کرنے کاباعث بنی ہے اس کے متعلق بھی عام قیاس یہ ہی ہے کہ وہ ایل ٹی ٹی گروہ سے تعلق رکھتی ہے۔مگرابھی یہ سب قیاس آرائیاں ہی ہیں،یقین و قطعیت سے کچھ نہیں کہا جاسکتا ہے۔حکومتِ ہند نے تمام حادثۂ قتل کی تحقیقات کے لیے بروقت ایک کمیشن بنادیا ہے جوعرصہ تین ماہ میں اس سلسلے میں اپنی رپورٹ پیش کرے گا۔ اس سے پہلے جوبھی اس سلسلے میں اظہار ِ خیال کرے گا وہ صرف قیاسات ہی کے زمرے میں ہوگا۔اورحقیقت ویقین کاگمان کرنا...

حضرت محمدﷺ کے معجزۂ معراج اور اسراء کے متعلق سرسید احمد خان کا تصور

Amongst other miracles of the Prophet Muhammad (PBUH), ISRAA and MAIRAAJ are one of the well-known miracles that have been discussed a lot in Sirat-ul-Nabi. This article, therefore, has brought under discussion the occur-rence of this miracle in the light of Qura’n and Ahadith in details.  Furthermore, it has also been discussed whether the occurrence of this miracle was physical or spiritual in its nature.  The concept of Sir Syed Ahmed Khan regarding this miracle has also been discussed; where he support his arguments with reference to some Ahadith, that the entire situation concerning the miracles was merely a dream and this miracle did not take place in physical form. According to him, this is against the law of nature. In this article the explicit concepts of Sir Syed Ahmed Khan have been rejected with the arguments given by the Majority of the Scholars and Muslim thinkers.

Archetypal Identification and Psycho Psycho- Spiritual Well Being: the Influence of Well-Being: Archetypal Polarity on Religiosity Hetypal Spirituality and Neuroticism

The concept of personal growth is highly important for human welfare. According to Jungian model of human development, personal growth and maturity refers to the search for completion which is universal, cross-cultural, and spiritual (Freeman, 2006). Using holistic approach, the question of the personal growth and maturity in relation to psycho-spiritual wellbeing has been explored in the sample of 500 adult population of Khyber Pukhtunkhwa. The sample was composed of 262 men (52.4%) and 238 women (47.6%), whose age ranged from 17 to 47 with the mean age of 26.05 ± 6.381. The personal growth was gauged through the Pearson-Marr Archetype Indicator (Pearson, 2002). Spiritual Wellbeing Scale by Paloutzian and Ellison (1991) was used to measure existential and religious wellbeing which was supplemented with Subjective-Psychological Wellbeing Scale of Diener and Biswas-Diener (2008). Later, the two scales were validated against the Islamic Religiosity Scale (Khan, 2006) and Depression Anxiety and Stress respectively. The results were discussed in terms of hypotheses involving the meditating role of archetypes in psychological maturity and psycho-spiritual wellbeing. The evidence implicating psychological maturity in the determining of religiosity, spirituality and wellbeing was compelling. All of the main and most of the secondary predictions were confirmed. Multiple comparisons showed significant relationship of psychological maturity with age, gender and early life experiences of the respondents, F (2, n=500), 127.686, p<.01.; X2 (2, n=500) 33.476, p<.01.; and X2 = (9, n=500) 125.46, p<.01., respectively. As predicted, it was discovered that psychologically mature respondents obtained higher scores on all measures of subjective-psychological and spiritual wellbeing. Spiritual poverty apparently resulted when a respondent’s major identification was with the lower levels of ego and soul. Moreover, neurotic tendencies significantly reduced with psychological maturity and religious participation. As such these results confirm the importance of psychological maturity on psycho-spiritual wellbeing. ii