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Home > Phytochemical Investigation and Phytocosmetic Formulation Development of Berries from Solanaceae Family: in Vitro In-Vivo Characterization

Phytochemical Investigation and Phytocosmetic Formulation Development of Berries from Solanaceae Family: in Vitro In-Vivo Characterization

Thesis Info

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Author

Hameed, Abdul

Program

PhD

Institute

The Islamia University of Bahawalpur

City

Bahawalpur

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Pharmaceutics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/11166/1/Abdul%20Hameed_Pharmaceutics_2019_IUB_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726923011

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The current research work was initiated to study the phyto-chemical composition, antioxidant potential and tyrosinase enzyme inhibition capacity of berries of different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), in methanolic extract and fractions of various non-polar to polar solvents . The formulations were developed and their rheological characteristics, impact on solar protection factor (SPF) and various parameters were assessed on healthy human volunteers using Skin VisioFace® and Non-Invasive probes. The data were compared and correlated to examine the possible relationship between facial pores, skin elasticity and skin sebum. Skin elasticity by Cutometer and Elastometer and sebum by Sebumeter was correlated with number of fine and large facial pores. The total flavonoids contents present in WSEA (96.91 ± 1.56 µg QEmg-1 ) while total phenolicscontents were quantified (178.45 ± 2.78 μg GAEmg-1 sample,.) and SNEA (89.58 ± 0.98 µg QE mg-1 sample and 120.15 ± 2.33 μg GAEmg-1sample, resp.). HPLC-DAD analysis of ethyl acetate fractions of both plants (WSEA and SNEA) was performed and confirm the presence gallic acid, caffeic acid,kaempferol and rutin. . The droplet size of fresh herbal cosmetic formulations F1 (WSEA) and F2 (SNEA) was found to be 2.04±0.577µm and 2.31±0.532µm with thixotropic value 16964±41 (D/cm2.s) and 16471±35 (D/cm2.s) respectively. The solar protection factor at optimum thixotropic values of both formulations F1 and F2 was 3.11±0.34 and 2.34±0.12 respectively. At accelerated stability conditions, there was a minute reduction in the formulation consistency due to decrease in viscosity and increase in droplet size. The herbal cosmetic good SPF was due to the presence of polyphenols, which shield the skin from harmful UV radiations. It was observed that phytoformulation demolished the total count/size of fine and large pores of each volunteer and also had pronounced effect on mechanical properties of skin, skin pigmentation and skin moisture contents. The formulations with natural phenolic compounds showed strong antioxidant activity with positive effect of various skin characters.
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پروفیسر مشیر الحق

پروفیسر مشیرالحق مرحوم
دارالمصنفین اور پوری علمی دنیا میں جناب پروفیسر مشیر الحق مرحوم وائس چانسلر کشمیر یونیورسٹی کے سانحہ قتل کی خبر نہایت رنج و غم کے ساتھ سنی گئی، ان کو یرغمال بنائے جانے کی خبر ہی باعث تشویش اور اضطراب تھی، لیکن یہ امید نہ تھی کہ ایک حلیم الطبع، نرم شائستہ و شگفتہ مزاج انسان کے خرمن ہستی کو آتش چنار اس طرح جلاکر خاک کردے گی۔
ان کی زندگی ماہ و سال کے لحاظ سے بہت زیادہ نہیں ہے لیکن محنت، صبر، استقلال عزم اور مقصد کی یافت کے لحاظ سے یہ حیات مختصر بڑی قابل قدر اور قابل رشک رہی۔ ان کے علمی سفر کا آغاز دارالعلوم ندوۃ العلماء کی طالب علمی سے اور اختتام کشمیر یونیورسٹی کی وائس چانسلری پر ہوا، حق یہ ہے کہ قدیم و جدید کے خوشگوار اور متوازن امتزاج کی یہ دلکش مثال ہے۔
وہ غازی پور یوپی کے قصبہ بحری آباد میں پیدا ہوئے، کم عمری میں والد کے سایہ عاطفت سے محروم ہوگئے، تعلیم کے لیے دارالعلوم ندوۃ العلماء لکھنؤ آئے، یہاں سے عالمیت کی سند لی، انھوں نے انگریزی تعلیم پر بھی توجہ کی اور بڑے نامساعد حالات اور سخت معاشی پریشانیوں کے باوجود انھوں نے علم و فن کی تحصیل جاری رکھی ان کے علمی شوق و ذوق کو ان کے محبوب و مشفق استاذ مولانا عبدالسلام قدوائی ندوی مرحوم کی حوصلہ افزائی اور سرپرستی کبھی کم نہ ہونے دیتی، جامعہ ملیہ اسلامیہ سے بی اے اور علی گڑھ یونیورسٹی سے ایم اے کیا، ۶۱؁ء میں انھوں نے کناڈا کی میک گل یونیورسٹی سے پی ایچ ڈی کی سند بھی حاصل کی، دوران تعلیم ان کے قلب و نظر پر مولانا عبدالسلام قدوائی ندوی، پروفیسر محمد مجیب، پروفیسر سید عابد حسین اور پروفیسر الفریڈ کینٹویل اسمتھ کے نقوش خاص طور پر...

مروجہ جاگیردارانہ نظام کا تاریخی ارتقاء اور اسلامی تعلیمات کی روشنی میں تقابلی جائزہ

Islamic theory of possession is explicit. It is different from the contemporary feudal system. Islam does not believe in any tribe, nation and ancestry. Islam negates the concept of lordship and slavery. The history of Islam tells us that Muhammad (PBUH) awarded the property to the companion but it was a special gift and his purpose was not to rule. The purpose of feudal system is to land a certain class for political purpose. The Islamic concept of possession is different from feudal system. It is not correct to say that Islam allows the contemporary feudal system

Estimation of Biodiversity and Physio-Genetic Parameters for Drought Tolerance in Maize Zea Mays L.

Maize genotypes including 64 in number were evaluated at early stage in greenhouse with the soil having 40-100% moisture levels for different seedling parameters on various genetic analysis revealed that the highest estimates of heritability were found for root fresh weight, root volume and shoot fresh weight, at 40% soil moisture providing the evidence that these plant characters are under the control of additive genetic effects. The results showed that selection should evolve the genetic material with improved characteristics within short time. The single linkage cluster analysis and principle component analysis identified the variation among these parameters and in genotypes under the different moisture levels. Genotypes 21 in number with moderately tolerant and drought susceptible backgrounds were further evaluated by using Inter simple sequence repeats markers to ascertain their biodiversity. So 14 number of parents with determined diversity were finally selected and were crossed in line x tester fashion and their F1 along with their related parents were grown using randomized complete block design with 3 replications under normal and 50% of normal irrigation field conditions. All the cultural and other practices were kept uniform to both plantings except irrigation. Various agronomic and physiological parameters were recorded and analyzed for analysis of variance, genotypic and phenotypic correlation, principle component analysis, cluster analysis, general combining ability analysis and specific combining ability analysis for both conditions. Highest range of broad sense heritability with higher genetic advance regarding different plant characteristics depicted that these plant characters were controlled by additive genetic effects. So, it indicates that a fast genetic improvement is found in the experimental material. Clusters with superior genotypes showed the genetic potential of accession to transfer the desirable genes to improve yield in maize. The best combiners for both normal and 50% of normal irrigation field conditions were L3 x T4 (015114 x EV-6098), L9 x T4 (015129 x EV-6098), L9 x T1 (015129 x Sahiwal-2002). These crosses might be useful as transgressive seggregants in subsequent generations. The lines viz 014955, 015084, 015114, Sahiwal-2002, Agaiti-2002, Ev-5098 and Ev-6098 were found as best parents. These lines may be exploited in future breeding program for drought conditions. On the basis of different inheritance pattern of each parameter, it was suggested that overall performance of the lines and their all possible combinations might be more useful while selecting for water stress condition.