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Post Mastectomy Radiotherapy in Ca Breast a Comparison of Three Protocols

Thesis Info

Access Option

External Link

Author

Shahid, Dr. Abubaker

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Natural Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/1643

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726973187

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This trial was designed to compare three hypofractionated protocols in postmastectomy cancinoma breast in terms of local control, toxicity & work load. A total of three hundred patients suffering from ca breast stage T2-4 , N any, M0 were randomized into three arms after mastectomy. All the patients were treated with four fields on Co60 i.e. two tangential portals for chest wall, one anterior supraclavicular & axillary field & a posterior axillary boost and were randomized into three arms i.e. 2700 CGy in 5 fractions (one week) arm A, 3500 CGy in 10 fractions (2 weeks) arm B and 4000 CGy in 15 fractions (3 weeks) arm C. Skin, cardiac, pulmonary and hematological toxicities & lymphedema were compared in addition to local control and work load. The locoregional relapses were 11%, 12% and 10% in arms A, B & C respectively. 26%, 24% & 28% patients developed metastatic disease and 17%, 18% & 20% died in the three arms. G3 & G4 skin toxicities were 37%, 28% & 14%. G2 and G3 lymphedema was 21%, 22% & 27%. Cardiac toxicity was 5%, 6% & 5% while pulmonary toxicity was 4%, 5% & 5% respectively. All the differences except skin toxicity were statistically insignificant. There were no cases of hematological depression or rib fractures. All the three short protocols were equally effective in locoregional disease control and toxicity was also comparable. They were helpful in reducing the work load and can be safely recommended for routine clinical use.
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خواجہ غلام السیدین

خواجہ غلام السیدین
افسوس ہے کہ خواجہ غلام السیدین بھی دنیا سے رخصت ہوگئے، ان کی موت علمی دنیا کا اندوہناک حادثہ ہے، وہ علی گڑھ کی بہترین پیداوار اور اس کا مثالی نمونہ تھے، اﷲ تعالیٰ نے ان میں علم و فضل، فکر و نظر، تقریر و تحریر، تالیف و تصنیف بہت سے کمالات جمع کردیئے تھے، اردو اور انگریزی دونوں زبانوں میں ان کو بڑی قدرت تھی، تعلیم کے ماہر خصوصی تھے، ان کے خیالات میں گہرائی کے ساتھ بڑا اعتدال و توازن تھا اور وہ مغربی تعلیم اور مشرقی تہذیب کا سنگم تھے، وہ نئے دور کی پیداوار تھے اور جدید علوم و افکار میں مہارت کے ساتھ راسخ العقیدہ مسلمان بھی تھے، ان کے دل میں اپنے مذہب و ملت کا درد تھا، اگرچہ بعض مسائل میں وہ جدید خیالات سے متاثر تھے، لیکن اسلام کی ترجمانی کا پورا حق ادا کرتے تھے، انھوں نے قلم و زبان دونوں سے مذہب و ملت کی خدمت انجام دی، ان کو ہندوستان اور اس کے باہر بڑے بڑے علمی اعزاز حاصل ہوئے اور مختلف علمی، تعلیمی، مذہبی اور ادبی موضوعات پر انگریزی اور اردو دونوں زبانوں میں تصنیفی یادگار چھوڑیں، ان کی تصانیف بڑی فکر انگیز ہیں، اﷲ تعالیٰ ان کی مغفرت اور دنیا کی طرح آخرت کی سربلندی سے بھی سرفراز فرمائے، یوں تو آئے دن موتیں ہوتی رہتی ہیں، مگر جب کوئی معاصر اور ہم عمر اٹھتا ہے تو اپنا وقت بھی قریب نظر آتا ہے۔
بہت آگے گئے باقی جو ہیں تیار بیٹھے ہیں
(شاہ معین الدین ندوی، جنوری ۱۹۷۲ء)

 

نصاب سازی میں تربیتی واخلاقی جہات: عصری ترجیحات اور فقہ السیرۃ

For the development of Muslim society it is necessary that its people should be trained on the basis of Islamic teachings. This could not be possible until we design a curriculum of seerah which is according to the contemporary needs of character building. The purpose of designing such curriculum is to train our youth in such a way that they would be able not only to take advantage from our rich tradition but also they are well prepared to hold the leadership of the country. We have to keep in mind, while designing seerah curriculum, that it is not revealed. Infact we have to design it according to the needs of hour. If we keep in consideration the ideological and contemporary requisites than we would be able to get the desired results. Islam provides basic principals in this regard. Following these instructions we would be able to design a curriculum which produced the required results.

Development and Validation of Self-Report Measure of Emotional Intelligence for Heart Patients and Healthy Individuals

Emotional Intelligence is emerging as an important area of inquiry for researchers in psychology. The construct is characterized as understanding and managing emotions in oneself and in others. This newly introduced concept of Emotional Intelligence is considered to have an influence on an individual’s success and health. The purpose of the present research was to create a valid instrument in order to measure the levels of emotional intelligence in heart patients and in healthy population. The study was conducted in three parts, the development of the scale, the validation study, the administration of the newly developed instrument on cardiac patients and healthy population and exploring difference between the two groups. The purpose of the first part of the research was the development of measure named as Self Report Measure of Emotional Intelligence (SRMEI). The non availability of an indigenous instrument to measure emotional intelligence specific to Pakistani cultural context provided a rational for the development of Self-Report Measure of Emotional Intelligence. The Part II of the research comprised a validation study which served to determine the convergent and discriminant validation of the scale. BarOn’s EQ-i and personality Mini Markers were used to determine convergent validity and Beck Depression Inventory was used to determine discriminant validity of SRMEI. The study also focused to explore the difference on emotional intelligence in respect of some of the demographic variables. In Part III of the research main study was conducted with (N = 400) individuals. The sample comprised of two independent groups. The group one included patients suffering from ischemic heart diseases (IHD), (N = 200), and the second group included healthy individuals (N = 200). In this part of the research emotional intelligence was studied with the help of newly developed research instrument of SRMEI to see the difference between the two groups on emotional intelligence. Consistent with our predictions the research showed that IHD patients may have emotional intelligence deficit as compared to healthy individuals. The difference was computed with the help of t- test and ANOVA. We expected to find that IHD patients will show lower levels of emotional intelligence than healthy individuals. The findings confirm our hypothesis, as the patients displayed significant deficit in the abilities of emotional self-regulation and emotional self-awareness. This research may contribute to a better understanding of emotional intelligence competencies which may have positive or negative impact on cardiac health. People suffering from ischemic heart diseases may lack some emotional competencies as compared to healthy individuals. Furthermore, this study would be helpful in highlighting the areas of emotional relearning in heart patients to improve their cardiac health conditions and for healthy individuals to identify their emotional intelligence deficiencies and strengths.