The work reported here has been carried out to Quetta Valley in air, food and water. 1600 samples of Almond, Pistachio and Walnuts and peanuts were collected seasonally from different parts of explore pollutants of Quetta city and examined qualitatively and quantitatively for the presence of Mycotoxin. Peanuts were found to be highly contaminated by saprophytic fungi Aspergillus infection flavus Walnuts . pistachio, by followed Almond and Level of Af latoxin in Peanuts was found to be highest among four. Aflatoxin level in Peanuts was 80 ppb, Pistachio 70 ppb, Almond 25 ppb and Walnut 20 ppb . Fungal infections and subsequent aflatoxin production was high during temperature summer and and autumn moisture seasons due to high Correlation contents. of aflatoxin with liver cancer was discussed. The degree of air pollution was determined on heavy traffic areas using road side trees as an indicator. The leaves of Cupressus sp, Pinus, Fraxinus, excelsior, Rubinea. Pseudoaccasia were collected and analyzed for micro, macro and heavy metals concentration. The detection and estimation of these elements was done by using atomic absortion spec.trophoto meter. Significantly high lead, Nickel Manganese cadmium, Iron, and Zinc contents were found. These highly toxic for all living systems and cause adverse effects directly or indirectly on human health. The common source of Lead, cadmium Nickel, Zinc, Iron and Manganese on tree leaves is motor vehicles. The heavy metal concentration increases with increasing distance from the This study showed that maximum pollution is on road. Jinnah Road to access the disease caused by pollution, 16 diseases of minor and major characteristics were A questionnaire was distributed to 1000 selected. selected shopkeepers randomly and residents of heavy traffic fifteen roads of Quetta city. These were 95.1% respondents resulted in a 95.1% return. The significance of lead as a health hazard in the Quetta City was calculated. The regression eolations were developed and generalized for the larger population using the data in hand. It was observed that blood pressure, E.N.T, Fatigue gasteo intestinal diseases and There is a cancer are highly correlated with lead. impact relationship linear hazardous of between diverse profession and the number of patients of various diseases, x test is used loi determining the significance of pollutants on patient s oi pollutants on various diseases, thereby rejecting our null hypothesis. water samples seasonally collected from different municipal water supplies of Quetta City were microbiological and their Chemical for analyzed characteristics . Calcium, Magnesium, Sodium, Potassium, Carbonate, Bicarbonate, Chloride, Sulphate, Nitrate, Boron dissolved solids, pH conductivity total Cations, total anions, Chromium, Lead, Nickel, Cadmium, Iron and Zinc, were determined quantitatively. The presence of indicator bacteria in potable water was found to be an important and interesting topic Most of . the work done in this regard was based on the enumeration of indicator bacteria in the water samples. In environment getting polluted by human and animal waste . Coliform and fecal coliform populations were found abundantly fecal streptococci were also isolated. This situation further intensifies hazardous of fecal pollution. the threat of the