اسلام میں اکل بالباطل اوردھوکہ دہی کی ممانعت

Financial dealings are an integral part of human life. All the human beings have to do such dealings for their needs, mostly related to trade. But principles and rules for such dealings depend on either human intellect or the Shariah teachings. The human intellect in itself prevents humans from indulging into oppressive and corrupt ways of earning so that they do not incur loss in trading. But selfish and lustrous worldly interests mislead them, and consequently, they take to the prohibited ways of earning. In such situations, Shariah guides us to the right path. Allah Ta’ala has guided the mankind in the best way through the eternal and everlasting teachings of the Holy Quran. Regarding the financial dealings, this Holy Book has given us a comprehensive guideline which is beyond human intellect, and that is: Do not get one another’s possessions through prohibited ways; yes, you can earn them through trading based on mutual consent. This guideline has prohibited all the illegal ways of earning, including fraudulence, dishonesty, misrepresentation etc. The Article in focus discusses the condemnation of earning through prohibited ways, importance of the unambiguity of financial dealings and the related Shariah rulings.

Relationship B/W C1418t Segment of Tm Gene Polymorphism With Coronary Artery Disease Patietns in General Adult Population of Karachi, Pakistan

Background Coronary artery disease is one of the leading causes of mortality and morbidity around the world. The Indo-Pak sub-Continent has one of the highest predispositions to Coronary artery disease. Apart from the established risk factors such as diabetes mellitus, hypertension, smoking, alcohol intake, family history, and obesity that played an important role in the development of CAD, genetic polymorphism also emerge as a risk factor in the incidence of Coronary artery disease. Thrombomodulin (THBD) gene is one of them. It is a transmembrane protein expressed on the surface of endothelial cells. It is an important vasoprotective and thromboresistant substance. This natural anticoagulant abates thrombin’s activity and activates Protein C. The relationship between Thrombomodulin gene polymorphisms and coronary disease remains Controversial. It has been reported that a single nucleotide polymorphism (CT) at position 1418 of thrombomodulin gene results in amino acid change from alanine (A) to valine (V) at protein position 455 of TM gene (Ala 455 Val). A considerable number of studies conducted across the globe showed a varied relationship between TM gene polymorphism and coronary artery disease. Therefore the aim of the present study is to assess the association between TM gene Polymorphism and coronary artery disease in general adult Population of Karachi, Pakistan ii METHODOLOGY This is a case control study that was conducted in Tabba Heart Institute in association with National Institute of Blood Disease, Karachi. In this study we explore the association between C/T dimorphism that might predict as a risk factor for coronary artery disease in population of Karachi. We compared C/T dimorphism in 92 cases with 90 control subjects by allele specific amplification. RESULTS The frequency of CC, CT and TT genotype was 81 (90 %), 6 (6.7%) 3 (3.3%) in controls and 67 (72.8%), 20 (21.7%) and 5 (5.4%) in cases respectively. In case group the CT/TT genotype were found to be significantly associated with coronary artery diseases when compared with control group (p-value 0.009). Both cases and control were in Hardy Weinberg equilibrium (HWE), i.e. for cases HWE was (X2 = 3.81, p>0.05) and for controls HWE was (X2 = 19.4, p>0.05). CONCLUSION TM C1418T polymorphism appears as a risk marker in Coronary Artery Disease patients in the population of Karachi, Pakistan.