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Home > A Randomized Control Trial Comparing Weight Adjusted Dose Versus Fixed Dose Prophylactic Phenylephrine Infusion on Maintaining Systolic Blood Pressure During Caeserean Section under Spinal Anaesthesia

A Randomized Control Trial Comparing Weight Adjusted Dose Versus Fixed Dose Prophylactic Phenylephrine Infusion on Maintaining Systolic Blood Pressure During Caeserean Section under Spinal Anaesthesia

Thesis Info

Author

Mwaura, Lucy Wambui

Department

Anaesthesiology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728033602

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Background: Spinal anaesthesia is the standard of care for elective caesarean delivery. Its advantages over general anaesthesia include: decreased blood loss, reduced postoperative pain and faster recovery time. Despite these advantages, the sympathetic blockade induced by spinal anaesthesia results in 80 percent incidence of hypotension without prophylactic management. This hypotension can cause: nausea, vomiting, cardiovascular collapse or even loss of consciousness in the mother, and fetal acidosis. Current evidence supports co-loading with intravenous fluids in conjunction with the use of vasopressors as the most effective way to prevent and treat the hypotension. Phenylephrine is the accepted vasopressor of choice in the parturient. A prophylactic phenylephrine infusion combined with a fluid co-load is proven to be an effective and safe method of maintaining maternal hemodynamic stability. While most published studies have assessed the effectiveness of a prophylactic phenylephrine fixed dose infusion, no published study has assessed the effect of a prophylactic phenylephrine weight adjusted dose infusion on maintaining maternal hemodynamic stability following spinal anesthesia for cesarean delivery. Objective: Compare the incidence of hypotension between women undergoing elective caesarean section under spinal anaesthesia, assigned to receive prophylactic phenylephrine infusion at a fixed dose of 37.5 micrograms per minute versus a weight adjusted dose of 0.5 micrograms per kilogram per minute. Study design: A double blind Randomized Controlled Trial. Methods: One hundred and eight patients scheduled for non-urgent caesarean section under spinal anaesthesia were randomized into 2 groups (control group and intervention group) using a computer generated table of numbers. Control group; Prophylactic phenylephrine fixed dose infusion at 37.5 micrograms per minute. Intervention group; Prophylactic phenylephrine weight adjusted dose infusion at 0.5 micrograms per kilogram per minute Results: The two groups had similar baseline characteristics in terms of ; Age, sex, weight and height. There was 35.2% incidence of hypotension in the fixed dose group and 18.6% incidence of hypotension in the weight adjusted dose group. This difference was found to be of borderline statistical significance (p-value 0.05), and the difference in the incidence rates between the two groups was found to be statistically significant (p= 0.03). The difference in the incidence of reactive hypertension and bradycardia between the two groups was not statistically significant: p-value of 0.19 for reactive hypertension and p-value of 0.42 for the incidence of bradycardia. There was also no statistically significant difference in the use of phenylephrine boluses, use of atropine, intravenous fluid used and the number of
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47. Muhammad/The Prophet Muhammad

47. Muhammad/The Prophet Muhammad

I/We begin by the Blessed Name of Allah

The Immensely Merciful to all, The Infinitely Compassionate to everyone.

47:01
a. Those who disbelieve and obstruct others from pursuing the Path of Allah,
b. HE will let all of their good deeds go waste,
c. so they will find no reward for these in the realm of the Hereafter.

47:02
a. While HE will erase impieties and sinful trespasses of those who:
- believe, and
- practice righteousness, and
- believe in what has been sent on to Muhammad The Prophet - The Qur’an, and
- that it is the Truth from their Rabb - The Lord, and
b. HE will absolve them of their evil deeds and also set aright their hearts and improve their
spiritual situation.

47:03
a. That is so because those who disbelieve they follow the falsehood,
b. while those who believe they follow The Truth - The Qur’an - from their Rabb - The Lord.
c. That is how Allah gives people precepts of wisdom by similitudes of themselves.

47:04
a. Whenever you encounter in the battlefield those who disbelieve, then strike their necks,
until, when you have overpowered them, then hold them firmly as prisoners of war.
b. Thereafter, you can either free them graciously or hold them to ransom against payment or in exchange of Muslim captives, until the battle lays down its burdens.
c. That is the rule!
d. Yet if Allah so willed, HE alone would have defended HIMSELF against them,
e. but HE allows fighting so that some of you may be tested by means of others in the
battlefield.
f. As for those who would...

Murabaha Financing in Pakistan: A Practical Islamic Banking Aspect

Modes of financing in Islamic banking system are generally categorized as Sharaiah based financing like Musharakah, Mudarabah and Shariah compliant financing like Murabaha, Ijarah etc. Islamic banks should have adopted and promoted Sharaiah based financial instruments but instead they have been predominantly using Sharaiah compliant modes especially Murabaha due to some valid reasons. The aim of this paper is to highlight and know the level of satisfaction of the clients, businessmen, entrepreneurs, professionals, academicians and Islamic banking experts of the prevalent structure and use of Murabaha by the Islamic banks in Pakistan.

Exploring Teachers Feedback Practices to Enhance Learning Outcomes of Students Studying in Grade V Social Studies Classrooms of Two Public Elementary Schools Located in Hunza, Gilgit-Baltistan

Formative assessment is an ongoing assessment process, and feedback is an integral part of formative assessment. It is an effective tool, used to enhance students’ learning in a classroom context. Teachers have the leading role in the whole process. The focus of this study was to explore teachers’ perceptions, understanding, and practices of formative assessment and the role of feedback practice in enhancing student’s learning. This study was conducted in two public schools of district Hunza, Gilgit-Baltistan, Pakistan. The design of the study employed was case-study under the qualitative research approach. Two social study teachers of Grade 5 participated in the study.The data were collected through semi-structured interviews, classroom observations, document analysis, and focus group discussions of students. The overall findings of my study indicate that the teachers were aware of some theoretical assumptions about the feedback with regards to its importance in supporting their students’ learning. However, the feedback practices were more mechanical rather than reflective. The findings indicate that teachers’ understanding and practices about feedback remained very theoretical and mechanicals. It was not evident if the feedback support learning in the broader term as discussed in the literature. The main aim of the formative assessment was to check the students’ work and identify correct or incorrect text/work. Even mistakes were seen in terms of spellings and factual knowledge since the tasks were limited in nature. Thus, the study suggests that teachers should equip themselves with the content and pedagogical knowledge of formative assessment and feedback practice in a classroom context. For this purpose, special continuous professional development courses could be arranged for teachers, through education department from national, provincials, districts and local levels, in order to make the formative assessment and feedback process effective and meaningful both for teachers and students.