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Home > Is There an Association Between Placental Inflammatory Lesions and Vaginal Microbiota in Preterm Labour? a Case Control Study

Is There an Association Between Placental Inflammatory Lesions and Vaginal Microbiota in Preterm Labour? a Case Control Study

Thesis Info

Author

David Ogechi Atandi

Department

Pathology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728055024

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Background: Preterm birth continues to be a significant contributor to neonatal mortality and morbidity despite diverse unique interventional strategies. There is need for better understanding of differences and influences of the now characterized vaginal microbiome on terminal inflammatory effects in the uterine microenvironment in term and preterm labour to improve on current strategies. How the existence of a postulated placenta microbiome also affects this understanding should be considered. Objectives: The aim of this study was to explore the association between the maternal vaginal microbiota and placental inflammatory lesions in preterm labour and to determine the presence of a placenta microbiome. Methods: In this nested study, we enrolled 36 case and control placentas in a 1:1 ratio matched for age and parity from women delivering preterm between 26 to 36 weeks gestation. The profile of bacteria in the vaginal tract and placenta was characterized and compared through 16S rRNA sequencing. All histologic inflammatory lesions were graded and staged as per recommended latest consensus guidelines on reporting placental lesions. Results: Preterm placentas were associated with greater rates of inflammation (43.3%) compared to term placentas (23.3%). Acute histologic chorioamnionitis accounted for the greatest proportion with higher rates in preterm (33.3%) than term placentas (6.67%). Placenta microbial samples had a sequence read success rate of only 5.7% bearing similarity to oral, environmental and vaginal tract bacteria. Conclusion: (1) Acute histologic chorioamnionitis was associated with preterm labour. (2) There is lack of evidence to support the existence of a placenta microbiome.
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چشم کشا انٹر ویو

چشم کُشا انٹر ویو

پاکستان پیپلز پارٹی کن حالات و مقاصد کے لیے قائم ہوئی ،پارٹی سے قبل لاہور کی کن شخصیات سے بھٹو صاحب کی قربت تھی ۔شہید بھٹو کی پارٹی کے قیام سے پہلے لاہور ،لائلپور ،گجرات کے دوروں کے دوران عوام کی طرف سے والہانہ اظہار محبت کے کیا کیا واقعات پیش آئے ،تاسیسی اجلاس میں لاہور ،قصور ،راولپنڈی ،فیصل آباد ،سرگودھا ،ملتان ،ساہیوال ،وہاڑی اور سندھ سے شریک ہو نے والے مندوبین کون تھے ۔لیفٹ کی بھٹو شہید سے نفرت کے محرکات کیا ہیں ۔ہالا کنونشن میں معراج محمد خان کی طرف سے پرچی کی بجائے برچھی سے خون سوشلسٹ انقلاب کے مطالبہ پر قائد عوام نے کیا جواب دیا ۔۔۔۔یہ سب کچھ جاننے کے لیے پاکستان پیپلز پارٹی کے بانی،رکن ،شہید بھٹو کے ساتھی ،ترقی پسند دانشور ،شاعر ،محقق و ادیب جناب اسلم گورداسپوری کا چشم کشا مضمون ۔

عام تاثر یہی تھا اور اب بھی ہے کہ پاکستان پیپلز پارٹی والے کھلے ،ڈلے ،منہ پھٹ ،سر کش ، اپنی لیڈر شپ کے ساتھ زیادہ فرینک قسم کے لوگ ہوتے ہیں جبکہ مسلم لیگیے عموما کاروباری ٹائپ ، میسنے ،موقع شناس و موقع پرست چاپلوس قسم کی طبیعتوںکے مالک ہو تے ہیں جوکبھی ’’گیلے ‘‘پر پائوںنہیں رکھتے ،رسک نہیں لیتے ،انتہائی لچکدار ’’کردار ‘‘کے حامل ہوتے ہیں ۔ماضی کی حد تک یہ تاثر شاید درست بھی تھا کہ معراج محمد خان ،مختار رانا آف لائلپور ،جے اے رحیم اور حنیف رامے جیسے نرم مزاج ،دانشور مصور فنکار قسم کے لوگ بھی بھٹو جیسے بندے کے خلاف ڈھے گئے ۔جبکہ مسلم لیگ کے مزاج میں سازش اور ٹانگیں کھینچنا تو موجود تھا لیکن آنکھوں میں آنکھیں ڈال کر مزاحمت کا رواج ہر گز نہیں تھا لیکن اب تو یوں محسوس ہوتا ہے کہ رولز ہی ریورس ہوگئے...

الاستدراك: أهميته وأثره في تفسير القرآن الكريم تبيان القرآن ومفاتيح الغيب نموذجا

Rectification is a terminology of Islamic Studies which means corrections of mistakes, completion of deficiency and clarification of ambiguity, it is a very special Quality of Islam due to its impacts and importance. Rectifications of Honourable Muslim Scholars on one another is a source for the innocency of this Ummah, here is the example of Rectification in the era of Sahahaba رضي الله عنهم and Tabieen and later, while the book of Eimam Al Hakim “Al Mustadrak Ala Sahehain” is an example of rectification at the time of Tabieen; in which he collects the narrations missed by Imam Bukhari and Imam Muslim in their books Saheeh Bukhari and Saheeh Muslim. The Honourable scholars follow this way in all the disciplines  of Islamic Studies especially in the field of Tafseer because they had rectifications on one another in their explanation of the Holy Quran. As for example Eimam Al Sayuti (911 AH) and Emam Aalusi (1270 AH) has rectifications in their explanations of Holy Quran on the Tafseer of Eimam Fakhr uddin Al Razi “Tafseer ul Kabeer”, while in our era Shaikh Ghulam Rasool Saeedi (1437 AH) follow the same way, and most of his ratifications in his Tafseer “Tibyan ul Quran” is related to Imam Razi. One thing which is unforgettable is that, these Scholars have maintained respect of personalities and opinions, furthermore they were mostly impartial in their research as well as tolerant while dealing with these issues even having different schools of thoughts etc. Their difference did not make them discourteous or impolite.

On the Monogenity of Cyclic Sextic Fields of Prime Conductor

In research of algebraic number fields, a construction of an appropriate integral basis plays a fundamental role. Researchers impose certain conditions on algebraic number fields in order to handle the hard problems of Algebraic Number Theory. For construction of an appropriate integral basis and determination of the relative monogenity and absolute monogenity, we select an algebraic number field, which is a composite field of cyclotomic field of conductor n and a totally real field of conductor m with (n;m) = 1 and also cyclic sextic field of prime conductor p with the prime discriminant p_: In this thesis we consider a classical problem of Algebraic Number Theory that an algebraic number field is monogenic or not, which was introduced in the 1960s by a German mathematician Helmut Hasse. In the case of composite field K = kn _ F; the methodology begins with the determination of units in the cyclotomic field kn to show that Zkn = Zk+ n [_]; where k+ n is the maximal real subfield of the cyclotomic field kn: By the consideration of any element of ZK taking the partial di_erent and its norm, we conclude that ZK has no power integral basis. Our methodology in the case of cyclic sextic field L begins with an algebraic integer _0 of L; where _0 denotes the Gau_ period of length p?1 6 : We established the non monogenic phenomenon in L by taking the relative norm NL=k(_0?__ 0 );NL=k(_0?__2 0 ) and NL=k(_0 ?__3 0 ) of the three partial factors _0 ?__ 0 ; _0 ?__2 0 and _0 ?__3 0 respectively of the di_erent dL(_0) by the way of the quadratic subfield k of L: Here _ is an automorphism _p ! _r p ; where r a primitive root modulo p and _p is a primitive pth root of unity. We conclude that _0 generates the power integral basis for the 7th cyclotomic field, maximal real subfield of 13th cyclotomic field and a field of conductor 32 only. In fact for any element _ of L; we have shown that _ cannot generate a power integral basis in the same way as _0 except for the above three sextic fields.