محمد فاروق نعمانی
افسوس ہے کہ ۲۶ و ۲۷؍ اپریل کی درمیانی شب میں جناب محمد فاروق نعمانی نے الٰہ آباد میں داعی اجل کو لبیک کہا، وہ مولانا شبلی کے برادر زادہ اور مولوی محمد اسحق صاحب وکیل ہائی کورٹ کے صاحبزادے تھے، جو اعظم گڑھ میں مولانا کے علمی و تعلیمی اور خاندانی جائداد اور زمینداری کے کاموں میں ان کے خاص دست و بازو تھے، ان کے انتقال پر مولانا نے ایسا پُر درد مرثیہ لکھا جو اردو کی عزائیہ شاعری میں بے مثال ہے، فاروق صاحب اس وقت کم سن تھے، اس کی طرف مولانا نے اس شعر میں اشارہ کیا ہے۔
لاڈلے ہیں کہ کسی اور کے بس کے بھی نہیں
اس کے بچے ابھی سات آٹھ برس کے بھی نہیں
فاروق صاحب شبلی کالج کے پرجوش اور سرگرم ممبر تھے، دارالمصنفین سے بھی ان کو گہرا اور جذباتی تعلق تھا، یہاں کی دعوتوں اور مجلسوں میں شریک رہتے، صوم و صلوٰۃ کے پابند تھے، لاگ لپیٹ ان کو نہیں آتا تھا۔ اﷲ تعالیٰ مغفرت فرمائے اور پس ماندگان کو صبر جمیل عطا کرے، آمین۔ (ضیاء الدین اصلاحی۔ مئی ۱۹۹۷ء)
Background: Chronic myelogenous Leukemia is a form of cancer that was firstly recognizes to associate strongly with the chromosomal abnormality [t (9; 22) translocation] called Philadelphia chromosome. Objective: Philadelphia chromosome is a characteristic chromosomal marker that is associated with chronic myelogenous leukemia. Methods: More than one hundred patients of either sex were selected for the experiment. RNA was isolated from whole blood of patients so can use exclusively in RT-PCR. Results: Philadelphia chromosome in blood samples of patients with suspected diagnosis of CML was detected in 63% of patients. During our experimental studies on CML patients we do not encounter any complex translocation involving chromosome 8, 9 and 22. Conclusions: Philadelphia chromosome is a precise cytogenetic marker the detection of which is significant for differential diagnosis and clinical organization of patients with clinical diagnosis of CML. It is of significant that Ph chromosome occurs in pre-leukemic stage and has great diagnostic significance.
The present phytochemical investigations described the isolation of chemical constituents from the stem of indigenous plant Murraya koenigii(L.) Spreng which is commonly known as curry plant. This thesis is divided into two parts. PART A Phytochemical studies of Murraya koenigii PART B Pharmacological investigation of isolated compounds In Part A, the introduction describes biosynthesis of carbazole alkaloids, their pharmacological importance and list of previously isolated chemical constituents.In the present study, total eleven different compounds have been isolated from the stemof M. koenigii. Among these isolated compounds eightwere identified as new compounds namely, aronine (66), afifine (67), jerinine (68), ferinine (69), atinine (70), zolidine (71), osinine (72) and2-methyl-3-(1-methyl cyclohex-2-en) propanol-ol (73). Moreover,other three known compoundsmurrayanine (1), mahinimbine (3) andgrinimbine (14) were also identified during this phytochemical work. In Part Bpharmacologicalactivities namely, antifungal and antibacterial and antioxidant activities of isolated compounds have been studied. The three compound girnimbine,murayanine and afifine showed antifungal activities and murrayanine and jerinine showed antibactrial activities against the tested strains. Furthermore, murrayanine, ferinine, girimbine, afifine and jerinine exhibited positive antioxidant activity.