تعلیمات قرآن کریم اور زبور کی تطبیق و تفریق

There have been many prophets in human history to guide  people on the right path. Some of them were revealed the Holy Scriptures. Muslims believe in all the heavenly books, as they were meant for the guidance of their respective Ummah (Nation). In the end Allah Almighty sent the Holy Quran which is complete and last message and a source of guidance for the whole mankind till the Day of Judgment. It is the only heavenly book which is found in its original form, because Allah Almighty has taken the responsibility to guard it. None of the other Holy Scriptures is found in its original shape. This protection has made it distinguished from all the other heavenly scriptures. However some teachings of the other Holy Scriptures have no contradiction to those of the Holy Quran; which terms this portion to be original and safe from human amalgamation. In the given article coordination (similarity) and contradiction of the teachings of the Holy Quran and those of Zaboor (Book of Psalm) have been compared and analyzed. First co ordinations and then contradictions have been discussed.

A Study on the Synthesis and Biological Evaluation of Some 3, 6-Disubstituted-1, 2, 4-Triazolo[3, 4-B]-1, 3, 4-Thiadiazoles and 2, 5-Disubstituted-1, 3, 4-Oxadiazoles

The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents used as a cure against a number of human ailments. The present work deals with the synthesis of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4- thiadiazoles and 2,5-disubstituted-1,3,4-oxadiazoles bearing adamantyl and aryl moieties. The synthesis of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles was carried out starting from aryl carboxylic acids. On the other hand, 2,5-disubstituted-1,3,4-oxadiazoles were synthesized using two distinct routes starting from either aryl carboxylic acids or aryl nitriles. The structures of the synthesized compounds were confirmed by IR, 1 H- and 13 C-NMR, EIMS and XRD analysis. The target compounds were screened for their antitumor, antiviral, antibacterial and antifungal potential. Among the tested compounds, 3-(2-methylphenyl)-6-adamantyl- 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (4a) and 3-(2-fluorophenyl)-6-adamantyl-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazole (4d) exhibited prominent antiproliferative activity against human CD4 + T-cells containing an integrated HTLV-1 genome (MT-4) with CC 50 of 45 μM and 47 μM, respectively. These compounds were also found to be active against human acute T-lymphoblastic leukemia (CCRF-CEM) cell lines with CC 50 of 40 μM each. 3-(3-Methylphenyl)-6-adamantylmethyl-1,2,4-triazolo[3,4-b]- 1,3,4-thiadiazole (4n) showed moderate inhibition of HIV-1 and HIV-2 with EC 50 of >10.90 μg/mL, but no selectivity could be witnessed. Similarly, 3-(3-methylphenyl)- 6-adamantylmethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (5n) was found to be potent exhibiting moderate inhibition of HIV-1 and HIV-2 with EC 50 of >10.86 μg/mL. Furthermore, oxadiazole (9a) and 2-adamantyl-5-(2-(2-methylphenyl)-1,3-thiazol-4-yl)-1,3,4- 2-adamantyl-5-(2-(2-bromophenyl)-1,3-thiazol-4-yl)-1,3,4- oxadiazole (9j) showed significant inhibition of HIV-1 and HIV-2 with EC 50 of >10.50 μg/mL and >10.90 μg/mL, respectively. However, antibacterial and antifungal activities of all the compounds were found to be non-significant at non-toxic concentrations.