Sejarah dan Eksistensi Ekonomi Islam pada Era Global di Asia Tenggara

Sharia Economics of Southeast Asian countries has been existing, with a close relationship with their society, since the early arrival of Islam and its spreading in this archipelago through the period of the Islamic Kingdoms up till today. The unity of this Islamic economy with its society because the society has made their identity as Islam so that their habits, customs, economic system, and Worldview are identical to Islam. However, the implementation of the Islamic economic system and its financial activities were interrupted by the existing of colonialism. After their independence from colonization, the country such as Malaysia, Indonesia, and Brunei Darussalam initiated to raise awareness and conducted studies on the Islamic economic system. Even the government has a commitment to achieve the World's prominent center of Islamic economy. This year's report by The State of global Islamic economists reveal that ASEAN countries have succeeded in positioning their countries as a largest of sharia financial center in the world.

Computer-Guided Design and Synthesis of Il-2 Inhibitors As Immunomodulating Agents

Cytokine Interleukin-2 (IL-2) has a prevalent role in the growth, activation, and differentiation o f T-cells. To suppress immune responses associated with organ transplant rejection and other autoimmune diseases, it is important to disrupt the interaction of IL-2 with its receptor system. IL-2 is now emerging as a target in the discovery of novel therapeutics for addressing the problems related to immune system. The main goal of this study was to establish an effective in silico protocol for identification of IL-2 inhibitors. It describes a pharmacophore based virtual screening combined with docking study as a rational strategy for identification of novel IL-2 inhibitors. Structure based pharmacophore model was developed using the crystal structure of IL-2/IL-2Rα (PDB ID: 1Z92) complex. The predictive pharmacophore model consisted of three features, two hydrophobic and one cationic feature with three excluded volumes. The pharmacophore was validated using a training set of thirty known IL-2 inhibitors. Pharmacophore model as a 3D search query was searched against ZINC and MOE database, in order to retrieve new chemical scaffolds that may be potent IL-2 inhibitors. The hits retrieved from this search were filtered based on their RMSD values and pharmacophoric features. Hits that were retained were used in a molecular docking study to find the binding mode and molecular interactions with crucial residues at the active site of the target. Pharmacophore based molecular docking was carried out on virtually screened compounds using 1Z92 as target by MOE software that led to the identification of 15 hits belonging to diverse classes of heterocycles. These hits were further optimized and a library of forty six compounds including 5-6 membered azaheterocycles namely dihydropyrimidines, heteroazepines, pyrazoles and benzimidazoles besides some compounds such as chalcones and Schiff bases, was designed and synthesized. All newly synthesized compounds were characterized by their MS and NMR spectral analysis. IL-2 inhibition studies on the members of the synthesized library led to the identification of novel IL-2 inhibitors with IC 50 values ranging from <2- >50μg/ml using cyclosporine as a standard drug. This entire set of experiments in both dry and wet labs led to a successful designing and synthesis of a variety of compounds as novel scaffolds that may be developed into interesting immunomodulators.