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Home > Study of Zinc Ferrite Containing Ferrimagnetic Bioactive Glass Ceramics for the Hyperthermia Treatment of Cancer

Study of Zinc Ferrite Containing Ferrimagnetic Bioactive Glass Ceramics for the Hyperthermia Treatment of Cancer

Thesis Info

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Author

Shah, Saqlain Abbas

Program

PhD

Institute

Government College University

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2004

Thesis Completion Status

Completed

Subject

Physics

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/1972

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727401851

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Ferrimagnetic bioactive glass ceramics are expected to be potential candidates for the hyperthermia treatment of cancer. When placed in an alternating magnetic field of high frequency, these materials generate heat energy by hysteresis and eddy current losses. Tumor cells usually perish around 43 °C due to the poorly developed nervous and circulatory system whereas healthy body cells remain unaffected at this temperature. Such materials should have the adequate ability to bond with the tissues (bioactivity). Much work has been done on Fe 3 O 4 containing glass ceramics for this purpose but present work is the first ever detailed study of its kind on ZnFe 2 O 4 containing ferrimagnetic bioactive glass ceramics for the hyperthermia treatment of cancer. Glass ceramics of the composition (%wt) xZnO • 25Fe 2 O 3 • (40 -x)SiO 2 • 25CaO • 7P 2 O 5 • 3Na 2 O were prepared by melt-quench method and subsequent sintering at 1100 °C. After sintering the materials were quenched to about -10 °C to cause ferrimagnetism by preserving the high temperature state of mixed spinels, i.e., random distribution of cations at tetrahedral (A) and octahedral (B) sites of the spinel lattice. Magnetic properties of ferrimagnetic materials were further enhanced by cooling the materials in an aligning magnetic field to cause anisotropy. XRD was used to study the crystalline phases in the materials. Magnetic properties of the materials were studied using VSM. The sample X10 (having 10% ZnO) exhibited the highest hysteresis area. Calorimetric properties were studied by placing the materials in a magnetic induction furnace. The sample X10 exhibited the best magnetic heat generation due to its highest hysteresis losses. Anisotropic materials showed better magnetic and calorimetric properties than the non-aligned materials. Materials were immersed in simulated body fluid (SBF) for 3 weeks to study the bioactivity. In Vitro characterization was carried out using XRD, FTIR, SEM, EDS, AAS & pH meter. The results confirmed that all samples were bioactive as layers of biological hydroxycarbonate apatite (HCA) appeared after 3 weeks. Sample X10 exhibited adequate bioactivity. Due to balanced calorimetric & biological properties, sample X10 was considered the potential material of choice to be used for the hyperthermia treatment of cancer as well as for re-enforcement of the damaged bones.
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لسانیاتی طریقہ مطالعہ

موضوع 9:لسانیاتی طریقہ مطالعہ
لسانیات کا تعلق زبان سے ہے اور زبان معاشرے کی تشکیل میں اہم کردار ادا کرتی ہے۔ زبان معاشرے پر انمٹ نقوش چھوڑتی ہے اورمعاشرہ زبان پر اثر انداز ہوتا ہے۔جب ہم زبان کا تقابل کرتے ہیں اور جائزہ لیتے ہیں تو مزید صورتحال واضح ہو جاتی ہے۔ زبان دنیا کے ہر حطے ہر کونے میں پائی جاتی ہے اور تغیر سے گزر رہی ہوتی ہے۔زبان کے کام اور ضرورت کو پیش نظر رکھتے ہوئے بہت سے ماہرین نے کانٹ چھانٹ کر کے زبان کے اصول و ضوابط کے مطابق رکھا اور تبدیلیاں منظر عام پر لائے۔
زبان کی تاریخ اتنی ہی پرانی ہے جتنی کے انسانی تاریخ۔ اردو میں ابتدائی لسانیات کے حوالے سے جنہوں نے کام کیا ان میں کچھ فرانسیسی ،اطالوی اور کچھ فرنگی تھے جوکہ زبان میں تبدیلیاں لے کر آئے۔ان میں زبان کی محبت، جستجو اور جذبہ تھا۔کسی بھی زبان کو سمجھنے کے لئے مقامی لوگوں سے رابطہ کرنا پڑتا ہے۔ جبکہ مقامی لوگ ان لوگوں کے کام کو وقت کا زیاں سمجھتے ہیں۔
لسانیات پر مشتمل کتابیں منظر عام پر آئیں اوران میں ادب کے حوالے سے اپنے خیالات نظریات کا اظہار کیا۔ اس میں سرسیداحمدخان کی قواعداردو شامل تھی۔ اس رسالے میں گرائمر کے مختلف قاعدے درج ہیں اس کا سن اشاعت 1840 ہے۔ اس رسالے کے متعلق مولوی عبدالحق لکھتے ہیں:
"اگرچہ یہ کتاب کچھ ایسی قابل لحاظ نہیں لیکن اس سے اس بات کا پتہ چلتا ہے کہ مرحوم کو اردو زبان سے کس قدر دلچسپی تھی۔"
سر سید احمد خان نے زبان کے لیے جامع قسم کی لغت کی ضرورت کو محسوس کیاانہوں نیاپنے عہدمیں اردو لغت مرتب کرنے کا بیڑا اٹھایا۔ انہوں نے اس لغت میں لفظ کی تعریف اور تشکیل کو بھی شامل کیا تھا۔ انہوں نے لفظ کی تعریف کی...

قضية مساواة المرأة بالرجل وقوامته عليها في ضوء القرآن الكريم

It is well fact that before the advent ofthe Prophet Mu hammad (PBUH) the whole world was in totally darkness. Oppression was the order of the day. Womenfolkwas the most depressed segment ofthe society but when Islam cameit notonlyenjoined it followers to strive for theestablishmentofa just society in all walks of life. The issues of oppression of women folk was particularly addressed. Many verses ofthe Holy Quran and Sunnah clearly elaborated the duties as well rights of women. Islam considers woman as equal to man in respect ofduties and rights keeping her physical difference in view. In this article six points have been chosen for discussion which are as under equality of woman with man in humanity, equality in rights and obligation, equality in ownership and employment, equality in responsibility and equality in punishments Equality in liaan process.

Citric Acid and 5-Aminlevulinic Acid Assisted Phytoremediation of Chromium Through Sunflower

Environmental pollution caused by heavy metals are of great concern now a day as it pose a great threat to human, animals and plants by entering into food chain and living tissue. A large number of heavy metals are being under consideration worldwide due to their potent environmental effects. Chromium (Cr) is one of them causing serious environmental damages. The irrigation of important food crops and vegetables with industrial and municipal wastewater might have human and animals to a significant health risk. For the remediation of heavy metal contaminated soils and water, the most economically effective, ecologically safe and environmental friendly technique is phytoremediation. Few hyper-accumulator edible crops such as, brassica and sunflower are subject to accumulate higher concentration of heavy metal from moderate to highly contaminated soils. Keeping in view the above scenario, this research was conducted to study the morpho-physiological and biochemical mechanisms of sunflower involved in Cr tolerance. Six Faisalabad Hybrids, FH-614, FH-600, FH-619, FH-620, FH-425, FH-612 varieties were selected and one best Cr tolerant variety was chosen for further experiments. The present study was divided into four sub studies. Prior to pot experiment, a short seed germination test was run under different Cr levels (0, 10, 50 and 100 µM) in petri dishes. The selected varieties were grown in Cr spiked soil (0, 5, 10 and 20 mg kg-1) in a pot experiment under natural conditions. Plant height, root length,fresh and dry biomass of root, stem and leaves, chlorophylls and SPAD value, carotenoids, water use efficiency (A/E), transpiration rate (E), stomatal conductance (gs)and photosynthetic rate (A) were measured. The enzymatic activities of antioxidants, such as ascorbate peroxidase (APX), superoxide dismutase (SOD), guaiacol peroxidase (POD), catalase (CAT), reactive oxygen species such as hydrogen peroxide (H2O2), malondialdehyde (MDA), electrolyte leakage and soluble proteins both in roots and leaves were also measured. Cr contents in roots, stem and leaves were determined. The best tolerant variety of sunflower FH-614 was screened and selected for further experiments. Then, same variety of sunflower (FH-614) was grown in Cr spiked soil (0, 5, 10 and 20 mg kg-1) and citric acid (CA) (0, 2.5 and 5mM) and 5-aminoluvulinic acid (ALA) (0, 10 and 20 mg L-1) with factorial arrangement to investigate the promoting role of ALA and chelating effects of CAin Cr stressed plants alone and in combinations. All morpho-physiological and biochemical attributes of sunflower were measured under Cr, CA and 5-ALA. The statistical data revealed that Cr significantly decreased the agronomic traits of all six selected hybrids along with biochemical and physiological changes. The second study (Cr +CA) showed same trend of Cr stress but the application of CA alleviated the Cr induced toxicity and also enhanced the Cr concentration and accumulation in plant tissues. The third study (Cr+5-ALA) depicts similar results to second study but the combined application of CA and 5-ALA under Cr stressed plants in fourth study showed additive effects in alleviating Cr induced toxicity and accumulation of Cr in plant tissues. In combined application, CA enhanced the mobility and solubility of Cr in soil while 5-ALA regulated the normal functioning of plant metabolism which capable plant to accumulate higher concentration of Cr and translocated it to higher parts (stem and leaves). The present study suggested that the combined application of CA and 5-ALA to sunflower plants grown in Cr contaminated soils can enhance the phytoextraction of Cr and a suitable management technique for the Cr contaminated soils. The possibility of combined CA and 5-ALA for other heavy metals and plants required more detailed studies in future to combat heavy metal pollution.